Lysine ingestion markedly attenuates the glucose response to ingested glucose without a change in insulin response
Lysine ingestion markedly attenuates the glucose response to ingested glucose without a change in insulin response
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DOI：
10.3945/ajcn.2008.27381
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发表时间：
2009-08-01
影响因子：
7.1
通讯作者：
Nuttall, Frank Q.
中科院分区：
文献类型：
--
作者：
Kalogeropoulou, Dionysia;LaFave, Laura;Nuttall, Frank Q.
背景：已知摄入蛋白质会刺激胰岛素和胰高血糖素浓度升高。为了解释这种效应，我们已开始测量单个氨基酸的作用。
目的：目的是确定赖氨酸摄入对胰岛素和胰高血糖素浓度的影响，以及这种影响是否受葡萄糖摄入的调节。
设计：13名健康受试者进行了4次研究。在禁食12小时后，于08:00分别给予水、25克葡萄糖、1毫摩尔赖氨酸/千克瘦体重，或赖氨酸加葡萄糖。在2.5小时期间测量血清赖氨酸、葡萄糖、胰岛素和胰高血糖素。所提供的赖氨酸量相当于一块672克（24盎司）牛排中所含的量。
结果：赖氨酸摄入导致赖氨酸浓度大约增加3倍，葡萄糖浓度略有下降。当赖氨酸与葡萄糖一起摄入时，2.5小时葡萄糖曲线下面积反应降低了44%（P<0.001）。胰岛素浓度在摄入赖氨酸后增加了约2倍，在摄入赖氨酸加葡萄糖后增加了约3倍（P<0.001）。胰高血糖素浓度在摄入赖氨酸后增加了约2倍，在摄入赖氨酸加葡萄糖后增加了约3倍（P<0.001）。
结论：赖氨酸摄入会增加胰岛素和胰高血糖素浓度，且这种作用在与葡萄糖一起摄入时会增强。这些结果表明，赖氨酸可能在调节血糖和激素反应方面发挥重要作用。
Background: Ingested proteins are known to stimulate a rise in insulin and glucagon concentrations. In our effort to explain this effect, we have begun to measure the effect of individual amino acids.Objectives: The objectives were to determine the effect of lysine ingestion on insulin and glucagon concentrations and whether the effect is moderated by glucose ingestion.Design: Thirteen healthy subjects were studied on 4 occasions. Water, 25 g glucose, 1 mmol lysine/kg lean body mass, or lysine plus glucose was given on separate occasions at 0800 after a 12-h fast. Serum lysine, glucose, insulin, and glucagon were measured during a 2.5-h period. The amount of lysine provided was equivalent to that present in a 672-g (24-oz) steak.Results: Lysine ingestion resulted in an approximate to 3-fold increase in lysine concentration and in a small decrease in glucose concentration. When lysine was ingested with glucose, the 2.5-h glucose area response decreased by 44% (P