Alveolar nitric oxide is related to periostin levels in idiopathic pulmonary fibrosis
Alveolar nitric oxide is related to periostin levels in idiopathic pulmonary fibrosis
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DOI：
10.23736/s0026-4806.19.06321-3
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发表时间：
2020-08-01
期刊：
影响因子：
4.7
通讯作者：
Bargagli, Elena
中科院分区：
文献类型：
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作者：
Cameli, Paolo;Bergantini, Laura;Bargagli, Elena
背景：特发性肺纤维化(IPF)是一种慢性进展性弥漫性肺部疾病，可在3-5年内导致慢性呼吸衰竭和死亡。在潜在的预后生物标志物中，肺泡一氧化氮(CANO)和Scrum Periostin显示可以预测这些患者的死亡率和疾病进展。方法：59例IPF患者(男性47例，年龄65.5+/-9.5岁)在锡耶纳间质性肺疾病区域转诊中心就诊。在这一人群中，我们回顾性地收集了诊断时呼出的多流一氧化氮参数和血清骨钙素，并分别与60名和8名健康志愿者的对照组进行了比较。结果：与健康对照组相比，IPF患者CANO水平升高，而Periostin水平无明显变化(P
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive diffuse lung disease leading to chronic respiratory failure and death in 3-5 years. Among potential prognostic biomarkers, alveolar nitric oxide (CaNO) and scrum periostin showed to predict mortality and disease progression in these patients. The aim of this study is to investigate potential correlations between CaNO and serum periostin and evaluate their prognostic value.METHODS: Fifty-nine patients with IPF (47 males, 65.5 +/- 9.5 years old) were recruited in Siena Regional Referral Center for Interstitial Lung Disease. In this population, we retrospectively collected multiple-flows exhaled nitric oxide parameters and serum periostin at diagnosis and compared these values with a control group of 60 and 8 healthy volunteers, respectively. Clinical, functional and survival data were collected according to our Center follow-up program.RESULTS: IPF patients reported higher levels of CaNO but not of periostin in respect with healthy controls (P