IMPACT OF ASYMPTOMATIC CONGENITAL CYTOMEGALOVIRUS-INFECTION ON SIZE AT BIRTH AND GESTATIONAL DURATION
IMPACT OF ASYMPTOMATIC CONGENITAL CYTOMEGALOVIRUS-INFECTION ON SIZE AT BIRTH AND GESTATIONAL DURATION
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DOI：
10.1097/00006454-199003000-00005
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发表时间：
1990-03-01
影响因子：
3.6
通讯作者：
ARMSTRONG, D
中科院分区：
文献类型：
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作者：
BERGE, P;STAGNO, S;ARMSTRONG, D
巨细胞病毒（CMV）是引起人类先天性感染的最常见病毒，影响所有活产婴儿的0.2%至2.4%。有症状的先天性巨细胞病毒感染先前已被证明会导致低出生体重和早产。无症状的先天性巨细胞病毒感染（占大多数病例（90 - 95%））是否影响宫内生长或妊娠期尚不清楚。采用多元回归技术对146名无症状先天性巨细胞病毒感染婴儿和1419名来自两个不同社会经济人群（低收入双种族和中高收入白人）的对照组进行研究，研究了体重的决定因素（出生体重和冠跟长度）。我们发现，在母体原发性和“未知”巨细胞病毒感染传播后的先天性感染导致低收入足月婴儿（黑人和白人）的平均出生体重不足163 g (P < 0.04)，但在中高收入白人婴儿中则没有。在母体再激活（复发性）巨细胞病毒感染传播后发生先天性感染的新生儿比对照组显着平均短1厘米（P < 0.03），这一发现与社会经济地位或种族无关。
Cytomegalovirus (CMV) is the most common viral agent causing congenital infection in humans, affecting 0.2 to 2.4% of all live births. Symptomatic congenital CMV infection has previously been shown to cause low birth weight and prematurity. Whether or not asymptomatic congenital CMV infection, which represents the majority of cases (90 to 95%), affects intrauterine growth or gestational duration is unknown. Using a population of 146 infants with asymptomatic congenital CMV infection and 1419 controls from two socioeconomically diverse populations (biracial low income and white mid- to upper income), determinants of body size (birth weight and crown-heel length) were investigated using multiple regression techniques. We found that congenital infection following the transmission of maternal primary and "unknown" CMV infection resulted in a significant mean birth weight deficit of 163 g (P < 0.04) for the low income term infants (blacks and whites), but not in the mid- to upper income white infants. Newborns with congenital infection following the transmission of maternal reactivated (recurrent) CMV infection were significantly shorter by a mean of 1 cm (P < 0.03) than controls, a finding that was consistent regardless of socioeconomic status or race.