Enantioselective Construction of Quaternary Stereocenters.
Enantioselective Construction of Quaternary Stereocenters.
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DOI：
10.1002/1521-3773(20011217)40:24
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发表时间：
2001-12
影响因子：
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通讯作者：
J. Christoffers;Alexander Mann
中科院分区：
文献类型：
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作者：
J. Christoffers;Alexander Mann
C-C键的立体选择性形成对于对映体纯的天然产物和药物的合成具有重要意义。多种手性助剂、试剂和催化剂可用于可靠地生成三级立构中心。相比之下，具有四元立构中心的有机化合物的合成是一项要求更高、更具挑战性的任务。每种对映选择性合成方法都可以通过生成完全取代的碳中心来证明其价值。在这篇小综述中，总结了较新的化学计量和催化方法的例子，这些方法已证明它们适用于四元立构中心的对映选择性构建。
The stereoselective formation of C-C bonds is of great importance for the synthesis of enantiomerically pure natural products and pharmaceuticals. A broad repertoire of chiral auxiliaries, reagents, and catalysts can be utilized for the reliable generation of tertiary stereocenters. In contrast, the synthesis of organic compounds with quaternary stereocenters is a much more demanding and challenging task. Every enantioselective synthetic method can demonstrate its value through the generation of a fully substituted carbon center. In this Minireview examples of newer stoichiometric and catalytic methods are summarized which have proved their suitability for the enantioselective construction of quaternary stereocenters.