A case of cowpox virus infection in the UK occurring in a domestic cat and transmitted to the adult male owner
A case of cowpox virus infection in the UK occurring in a domestic cat and transmitted to the adult male owner
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英国一例家猫感染牛痘病毒并传染给成年男性主人
DOI：
10.1111/bjd.19319
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发表时间：
2020
影响因子：
10.3
通讯作者：
A. Fityan
中科院分区：
文献类型：
--
作者：
C. Haddadeen;M. van Ouwerkerk;T. Vicek;A. Fityan
亲爱的编辑：一位43岁男性患者，左掌侧腕部有一个25 × 9 × 20 mm的波动性、无压痛、孤立性出血性大疱，伴中央坏死，左臂肿胀（第2、4和8天显示），淋巴管炎和38 5 °C发热。他的猫最近身体不适，出现了几十个3-4 mm的环状糜烂性病变。这些组织学表现为表皮坏死和脓肉芽肿性皮炎，角质形成细胞内有大量嗜酸性细胞质包涵体，这与痘病毒感染一致。英国公共卫生部（Porton Down，UK）对该男子的出血性大疱液进行了聚合酶链反应，鉴定出正痘病毒（疑似牛痘）。被银行田鼠感染的猫可以通过微小的皮肤裂缝将这种自限性疾病传播给人类，这些裂缝仍然局限于免疫功能正常的个体。40年前强制性牛痘疫苗接种的结束以及随后正痘病毒之间交叉保护的减少可能导致人畜共患正痘病毒感染的发病率增加。C. Haddadeen，M.货车乌沃克Vicek和A. Fityan皮肤科，大学医院南安普顿NHS基金会信托，南安普顿，英国;宠物兽医，兽医皮肤科，Thornhill，南安普顿，英国;和兽医病理学系，芬兰病理学家，哈勒姆，诺福克，英国通信：Adam Fityan。电子邮件：adam. uhs.nhs.uk
DEAR EDITOR, A 43-year-old man presented with a 25 9 20-mm fluctuant, nontender, solitary, haemorrhagic bulla with central necrosis on the left volar wrist, left-arm swelling (shown on days 2, 4 and 8), lymphangitis and pyrexia of 38 5 °C. His cat had recently become unwell and developed several dozen 3–4-mm erythematous annular and eroded lesions. These histologically demonstrated epidermal necrosis and pyogranulomatous dermatitis with large eosinophilic cytoplasmic inclusions within keratinocytes, which were consistent with poxvirus infection. Public Health England (Porton Down, UK) performed polymerase chain reaction of the haemorrhagic bulla fluid from the man, which identified Orthopoxvirus (suspected cowpox). Cats infected by bank voles can transmit the self-limiting disease to humans through minor skin fissures, remaining localized in immunocompetent individuals. The end of compulsory vaccinia vaccination 40 years ago and subsequent reduced cross-protection among orthopoxviruses may result in increased incidence of zoonotic Orthopoxvirus infections. C. Haddadeen, M. Van Ouwerkerk, T. Vicek and A. Fityan Department of Dermatology, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Pet Vet, Veterinary Dermatology, Thornhill, Southampton, UK; and Department of Veterinary Pathology, Finn Pathologists, Harleston, Norfolk, UK Correspondence: Adam Fityan. Email: adam.fityan@uhs.nhs.uk