Erythrocyte invasion by Babesia parasites:: Current advances in the elucidation of the molecular interactions between the protozoan ligands and host receptors in the invasion stage
Erythrocyte invasion by Babesia parasites:: Current advances in the elucidation of the molecular interactions between the protozoan ligands and host receptors in the invasion stage
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DOI：
10.1016/j.vetpar.2006.01.037
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发表时间：
2006-05-31
影响因子：
2.6
通讯作者：
Igarashi, Ikuo
中科院分区：
文献类型：
--
作者：
Yokoyama, Naoaki;Okamura, Masashi;Igarashi, Ikuo
在自然宿主中巴贝虫寄生虫的无性生长周期中，细胞外裂殖子通过几种原生动物配体与宿主细胞表面上的靶受体的多重粘附相互作用侵入（即附着、渗透和内化）宿主红细胞（RBC）。内化宿主红细胞后，它们无性繁殖，通过破裂宿主细胞从红细胞中排出，然后再次侵入新的红细胞。在侵袭阶段，裂殖子的一些表面涂层分子可能参与红细胞的初始附着，而顶端细胞器（棒状体、微线体和球形体）分泌的蛋白质主要在红细胞渗透或内化中发挥作用。另一方面，位于红细胞表面的几种成分，如唾液酸残基、蛋白酶敏感蛋白或硫酸化糖胺聚糖，被鉴定或怀疑为巴贝虫寄生虫侵入红细胞的宿主受体。巴贝虫裂殖子与宿主红细胞之间详细的分子相互作用尚不完全清楚。在这篇综述中，这些已识别或可疑的分子（原生动物配体/红细胞受体）的描述特别关注牛巴贝虫。 (c) 2006 Elsevier B.V. 保留所有权利。
During an asexual growth cycle of Babesia parasites in a natural host, the extracellular merozoites invade (i.e., attach to, penetrate, and internalize) the host erythrocytes (RBC) via multiple adhesive interactions of several protozoan ligands with the target receptors on the host cell surface. After internalizing the host RBC, they asexually multiply, egress from the RBC by rupturing the host cells, and then invade the new RBC again. In the invasion stage, several surface-coating molecules of merozoites might be involved in the initial attachment to the RBC, while proteins secreted from apical organelles (rhoptry, microneme, and spherical body) are proposed to play roles mainly in erythrocyte penetration or internalization. On the other hand, several components located on the surface of the RBC, such as sialic acid residues, protease-sensitive proteins, or sulphated glycosaminoglycans, are identified or suspected as the host receptors of erythrocyte invasion by Babesia parasites. The detailed molecular interactions between Babesia merozoites and the host RBC are incompletely understood. In this review, these identified or suspected molecules (protozoan ligands/erythrocyte receptors) are described by especially focusing on Babesia bovis. (c) 2006 Elsevier B.V. All rights reserved.