STRUCTURE OF THE HEMAGGLUTININ MEMBRANE GLYCOPROTEIN OF INFLUENZA-VIRUS AT 3-A RESOLUTION
STRUCTURE OF THE HEMAGGLUTININ MEMBRANE GLYCOPROTEIN OF INFLUENZA-VIRUS AT 3-A RESOLUTION
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DOI：
10.1038/289366a0
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发表时间：
1981-01-01
期刊：
影响因子：
64.8
通讯作者：
WILEY, DC
中科院分区：
文献类型：
--
作者：
WILSON, IA;SKEHEL, JJ;WILEY, DC
流感病毒的血凝素糖蛋白是由2个结构不同的区域组成的三聚体：α的三链盘绕。-螺旋延伸76 . ang。从膜和一个反平行的球状区域。-sheet包含受体结合位点和可变抗原决定因子，位于该茎的顶部。每个亚基具有不寻常的环状拓扑结构，从膜开始，延伸135 . ang。并向后折叠进入细胞膜。
The hemagglutinin glycoprotein of influenza virus is a trimer comprising 2 structurally distinct regions: a triple-stranded coiled-coil of .alpha.-helices extends 76 .ANG. from the membrane and a globular region of antiparallel .beta.-sheet, which contains the receptor binding site and the variable antigenic determinants, is positioned on top of this stem. Each subunit has an unusual loop-like topology, starting at the membrane, extending 135 .ANG. distally and folding back to enter the membrane.