Bipolar episodes after reproductive events in women with bipolar I disorder, A study of 919 pregnancies
Bipolar episodes after reproductive events in women with bipolar I disorder, A study of 919 pregnancies
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DOI：
10.1016/j.jad.2021.08.006
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发表时间：
2021-08-17
影响因子：
6.6
通讯作者：
Bergink, Veerle
中科院分区：
文献类型：
--
作者：
Gilden, Janneke;Poels, Eline M. P.;Bergink, Veerle
背景资料：患有双相I型障碍的女性在分娩后发生严重发作的风险很高，但没有研究概述妊娠期间和分娩后，流产和人工流产的双相发作风险。本研究的目的是确定发作的风险在所有的妊娠结局细分的第一次和随后的pregnances.Methods：参与者是436名妇女与双相I障碍的荷兰双相队列，有919怀孕，其中762导致活产，118结束流产和39结束人工流产。妇女报告在围产期发生躁狂或抑郁发作。结果：妊娠期和产后期的发病率分别为5.2%和30.1%，产后早期发病率最高。活产后的发病风险最高（34.4%），流产（15.2%）和人工流产（27.8%）后较低。与第一次妊娠无异常的妇女相比，在妊娠期间或产后有异常的妇女生育第二个孩子的可能性较小（cOR=0.34; 95%CI：0.22-0.51; p
Background: Women with bipolar I disorder are at high risk for severe episodes after childbirth, but there is no study that provides an overview on bipolar episode risk both during pregnancy and after childbirth, miscarriage and induced abortion. The aim of this study was to determine the episode risk during all pregnancy outcomes subdivided by first and subsequent pregnancies.Methods: Participants were 436 women with bipolar I disorder from the Dutch Bipolar Cohort, having 919 pregnancies of which 762 resulted in a live childbirth, 118 ended in a miscarriage and 39 ended in induced abortion. Women reported on the occurrence of manic or depressed episodes during the perinatal period. Information about medication use was obtained by questionnaires.Results: Episode risk was 5.2% during pregnancy, and 30.1% in the postpartum period, with a peak in the early postpartum period. Risk of an episode was highest after live birth (34.4%), and lower after miscarriage (15.2%) and induced abortion (27.8%). Women with an episode during pregnancy or postpartum were less likely to have a second child compared to women with an uneventful first pregnancy (cOR=0.34; 95%CI: 0.22-0.51; p