Perceptual deficits in amnesia: challenging the medial temporal lobe 'mnemonic' view
Perceptual deficits in amnesia: challenging the medial temporal lobe 'mnemonic' view
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DOI：
10.1016/j.neuropsychologia.2004.07.017
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发表时间：
2005-01-01
期刊：
影响因子：
2.6
通讯作者：
Graham, KS
中科院分区：
文献类型：
--
作者：
Lee, ACH;Bussey, TJ;Graham, KS
最近的动物研究表明，被认为专门为记忆服务的内侧颞叶（MTL）可能支持非记忆的感知过程，海马和周围皮层分别参与空间和物体感知。然而，这一观点在人类中没有得到支持，人类MTL病变在明显正常感知的情况下会导致显著的记忆缺陷。我们对失忆症患者的视觉辨别能力进行了评估，发现选择性海马损伤患者可以辨别人脸、物体、抽象艺术和颜色，但他们辨别空间场景的能力明显较差。相比之下，MTL损伤的患者，包括周围皮层，在区分场景、人脸和较小程度的物体方面明显受损，而对艺术和颜色的区分相对完整。这些新的观察结果表明，人类MTL具有感知和记忆功能，海马体和周围皮层分别在空间和物体识别中发挥着不同的作用。(C) 2004 Elsevier Ltd.版权所有。
Recent animal studies suggest that the medial temporal lobe (MTL), which is thought to subserve memory exclusively, may support non-mnemonic perceptual processes, with the hippocampus and perirhinal cortex contributing to spatial and object perception, respectively. There is, however, no support for this view in humans, with human MTL lesions causing prominent memory deficits in the context of apparently normal perception. We assessed visual discrimination in amnesic cases to reveal that while selective hippocampal damaged patients could discriminate faces, objects, abstract art and colour, they were significantly poorer in discriminating spatial scenes. By contrast, patients with MTL damage, including perirhinal cortex, were significantly impaired in discriminating scenes, faces, and to a lesser extent objects, with relatively intact discrimination of art and colour. These novel observations imply that the human MTL subserves both perceptual and mnemonic functions, with the hippocampus and perirhinal cortex playing distinct roles in spatial and object discrimination, respectively. (C) 2004 Elsevier Ltd. All rights reserved.