Factors related to persistent fatigue following completion of breast cancer treatment
Factors related to persistent fatigue following completion of breast cancer treatment
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DOI：
10.1188/04.onf.269-278
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发表时间：
2004-03-01
影响因子：
1.9
通讯作者：
Fillion, L
中科院分区：
文献类型：
--
作者：
Gélinas, C;Fillion, L
目的/目标：验证压力过程理论的预测能力，以解释持续疲劳后完成乳腺癌治疗，以验证白细胞介素-1 β和fatigue.Design之间的关系：相关性。设置：三级医疗中心在加拿大魁北克市。样本：一个系统的样本103名妇女在缓解乳腺癌被招募。平均年龄为54岁。参与者与抑郁情绪，失眠，或第四阶段cancer excluded.Methods：参与者在他们的后续任命结束后的放射治疗。疲劳，压力变量和其他混杂变量的问卷通过电话访谈完成。血液样本也被收集来测量白细胞介素-1 β的血清水平。主要研究变量：疲劳，从压力过程理论，疼痛，更年期症状，和人口和医疗variables.Findings的几个变量：疲劳理论上和连贯的许多压力过程变量。通过控制疼痛，最终的回归模型包括癌症压力源和被动和主动应对作为预测因子，占疲劳方差的41%。没有发现疲劳和白细胞介素-1 β之间的关系。结论：结果支持相关的压力过程理论解释癌症相关fatigue.Implications for Nursing：护理干预措施的基础上，这个理论框架可以开发。此外，建议进一步进行临床研究，以测试这些心理教育干预措施在预防持续疲劳和改善乳腺癌妇女生活质量方面的功效。
Purpose/Objectives: To verify the predictive capacity of the stress-process theory to explain persistent fatigue following completion of breast cancer treatments; to verify the relationship between interleukin-1 beta and fatigue.Design: Correlational.Setting: Tertiary medical center in Quebec City, Canada.Sample: A systematic sample of 103 women in remission from breast cancer was recruited. The mean age was 54 years. Participants with a depressive mood, insomnia, or stage IV cancer were excluded.Methods: Participants were met during their follow-up appointment after the end of radiation therapy. Questionnaires on fatigue, stress variables, and other confounding variables were completed by telephone interview. Blood samples also were collected to measure the serum level of interleukin-1 beta.Main Research Variables: Fatigue, several variables from the stress-process theory, pain, menopausal symptoms, and demographic and medical variables.Findings: Fatigue was related theoretically and coherently to many stress-process variables. By controlling for pain, the final regression model included cancer stressors and passive and active coping as predictors, which accounted for 41% of the variance in fatigue. No relationship was found between fatigue and interleukin-1 beta.Conclusions: The results supported the relevance of the stress-process theory for explaining cancer-related fatigue.Implications for Nursing: Nursing interventions based on this theoretical framework could be developed. In addition, further clinical research that tests the efficacy of these psycho-educative interventions in preventing persistent fatigue and improving the quality of life of women with breast cancer is recommended.