Frequency and timing of severe hypoglycemia affect's spatial memory in children with type 1 diabetes
Frequency and timing of severe hypoglycemia affect's spatial memory in children with type 1 diabetes
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DOI：
10.2337/diacare.28.10.2372
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发表时间：
2005-10-01
期刊：
影响因子：
16.2
通讯作者：
White, NH
中科院分区：
文献类型：
--
作者：
Hershey, T;Perantie, DC;White, NH
目的--反复发生的严重低血糖会降低1型糖尿病儿童的长期空间记忆能力。早期接触低甘油症对认知功能的损害可能比后来的接触更严重。我们的目标是确定发生严重低血糖的年龄是否调节了严重低血糖频率对长期空间记忆的影响。研究设计和方法-我们结合三项独立研究的数据，获得了6-18岁患有1型糖尿病的儿童(n=103)和非糖尿病对照组(n=60)的样本。每项研究都评估了先前的严重低血糖，并用空间延迟反应任务测试了短延迟空间记忆(5 S)和长延迟空间记忆(60 S)。1型糖尿病参与者被分类为有零、一到两次或三次或更多严重低血糖发作，并在5岁之前或之后首次出现严重低血糖发作。我们还收集了慢性高血糖(HBA(1c)值)的信息。结果：我们发现反复发生严重低血糖(超过3次)会降低长延迟空间延迟反应表现，特别是当严重低血糖发作在5岁之前开始时。1型糖尿病的发病年龄和对慢性高血糖的估计并不影响学习成绩。结论：在发育过程中，高频率和早期接触严重低甘油症对空间长期记忆成绩有负面影响。
OBJECTIVE - Repeated severe hypoglycemia has been reported to reduce long-term spatial memory in children with type 1 diabetes. Early exposure to hypoglycerma may be more damaging to cognitive function than later exposure. Our goal was to determine whether the age at which severe hypoglycemia occurs modulates the impact of severe hypoglycemia frequency on long-term spatial memory.RESEARCH DESIGN AND METHODS - We combined data from three independent studies to obtain a sample of children aged 6-18 years with type 1 diabetes (n = 103) and nondiabetic control subjects (n = 60). Each study evaluated previous severe hypoglycemia and tested short (5 s)- and long (60 s)-delay spatial memory with the spatial delayed response task. Type 1 diabetic participants were categorized as having zero, one to two, or three or more severe hypoglycemic episodes and as having their first severe hypoglycemic episode before or after 5 years of age. Information on chronic hyperglycernia (HbA(1c) values) was also collected.RESULTS - We found that repeated severe hypoglycemia (more than three episodes) reduced long-delay spatial delayed response performance, particularly when severe hypoglycemic episodes began before the age of 5 years. Age of type 1 diabetes onset and estimates of chronic hyperglycemia did not influence performance.CONCLUSIONS - High frequency of and early exposure to severe hypoglycerma during development negatively affects spatial long-term memory performance.