Sensitivities and Specificities of Diagnostic Tests and Infection Prevalence of Schistosoma haematobium Estimated from Data on Adults in Villages Northwest of Accra, Ghana
Sensitivities and Specificities of Diagnostic Tests and Infection Prevalence of Schistosoma haematobium Estimated from Data on Adults in Villages Northwest of Accra, Ghana
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DOI：
10.4269/ajtmh.2009.80.435
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发表时间：
2009-03-01
影响因子：
3.3
通讯作者：
Shiff, Clive
中科院分区：
文献类型：
--
作者：
Koukounari, Artemis;Webster, Joanne P.;Shiff, Clive
尿路血吸虫病诊断技术的敏感性和特异性存在很大的不确定性。我们使用潜在类（LC）建模来解决这个问题。在这项研究中，使用五种埃及血吸虫诊断措施对加纳阿克拉西北部三个村庄的 220 名成年人进行了检查：显微镜检查尿液以检测埃及血吸虫卵、用试纸检测血尿、循环抗原测试、抗体测试和泌尿系统超声扫描。 LC 模型的测试表明，不同年龄组的诊断测试性能没有不变性，并且男性和女性以及三个村庄的测量不变性。因此，我们建议使用 LC 模型来比较和识别最准确的血吸虫病诊断测试。此外，通过这些模型表明显微镜和血尿试纸是检测埃及沙门氏菌感染的最合适的技术。
Substantial uncertainties surround the sensitivities and specificities of diagnostic techniques for urinary schistosomiasis. We used latent class (LC) modeling to address this problem. In this study, 220 adults in three villages northwest of Accra, Ghana were examined using five Schistosoma haematobium diagnostic measures: microscopic examination of urine for detection of S. haematobium eggs, dipsticks for detection of hematuria, tests for circulating antigens, antibody tests, and ultrasound scans of the urinary system. Testing of the LC model indicated non-invariance of the performance of the diagnostic tests across different age groups, and measurement invariance held for males and females and for the three villages. We therefore recommend the use of LC models for comparison between and the identification of the most accurate schistosomiasis diagnostic tests. Furthermore, microscopy and hematuria dipsticks were indicated through these models as the most appropriate techniques for detection of S. haematobium infection.