Comprehensive MR imaging protocol for stroke management: Tissue sodium concentration as a measure of tissue viability in nonhuman primate studies and in clinical studies
Comprehensive MR imaging protocol for stroke management: Tissue sodium concentration as a measure of tissue viability in nonhuman primate studies and in clinical studies
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DOI：
10.1148/radiology.213.1.r99se15156
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发表时间：
1999-10-01
期刊：
影响因子：
19.7
通讯作者：
Erb, P
中科院分区：
文献类型：
--
作者：
Thulborn, KR;Gindin, TS;Erb, P
目的：探讨磁共振钠成像在监测卒中组织存活中的作用。材料和方法：将用于测量表观弥散系数和血流参数的综合磁共振成像方法扩展到包括钠成像。用二室模型估算组织钠浓度。这一方案持续了不到45分钟。在非人类灵长类动物模型(n=2)中，在没有或有溶栓治疗的急性栓塞性卒中中，对这些参数进行了前6小时的跟踪。该方案用于急性(
PURPOSE: To investigate sodium magnetic resonance (MR) imaging for monitoring tissue viability in stroke.MATERIALS AND METHODS: A comprehensive MR imaging protocol used to measure apparent diffusion coefficient and perfusion parameters was extended to include sodium imaging. Tissue sodium concentration was estimated by using a two-compartment model. This protocol lasted less than 45 minutes. These parameters were followed over the first 6 hours in a nonhuman primate model (n = 2) of acute embolic stroke without or with thrombolytic therapy. This protocol was used in patients in whom acute (