Glucagon-like peptide-2, but not glucose-dependent insulinotropic polypeptide, stimulates glucagon release in patients with type 1 diabetes
Glucagon-like peptide-2, but not glucose-dependent insulinotropic polypeptide, stimulates glucagon release in patients with type 1 diabetes
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DOI：
10.1016/j.regpep.2010.05.004
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发表时间：
2010-08-09
影响因子：
--
通讯作者：
Krarup, Thure
中科院分区：
文献类型：
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作者：
Christensen, Mikkel;Knop, Filip K.;Krarup, Thure
本研究调查了 8 名 1 型糖尿病 (T1DM) 患者的胰高血糖素样肽 2 (GLP-2) 和葡萄糖依赖性促胰岛素多肽 (GIP) 的胰高血糖素释放特性，而没有胰岛素的旁分泌胰岛内影响（5 g 静脉内精氨酸刺激后 C 肽呈阴性：在研究日仅用基础胰岛素替代治疗） 在 3 个研究日，180 分钟两步葡萄糖进行了夹紧。将血浆葡萄糖 (PG) 钳制在空腹值，前 90 分钟（第 1 期）的平均值为 74 +/- 05 mM，并在最后 90 分钟（第 2 期）将空腹值提高 1.5 倍，达到平均值 11.1 +/- 0 1 mM。按随机顺序使用 GIP、GLP-2。在前 50 分钟内，以模拟餐后激素反应的速率，在两个时期内静脉注射胰高血糖素或生理盐水。由此产生的胰高血糖素曲线下面积增量值分别在 1-38 +/- 44 (GIP)、120 +/- 48 (GLP-2) 和 -16 +/- 61（生理盐水）pM x 90 分钟 (p = 0.087) 和 2-157 +/- 时期分别为 76、135 +/- 52 和 -77 +/- 77 pM x 90 分钟 (p = 0019) 事后分析仅显示 GLP-2 天与 GIP 和盐水天之间存在显着差异 总之，发现 GLP-2（而非 GIP）可刺激 T1DM 患者胰高血糖素的释放，表明 GLP-2 在餐后高血糖中发挥作用，该患者的特点是餐后高血糖T1DM (C) 2010 Elsevier B.V. 版权所有
This study investigated the glucagon-releasing properties of the hormones glucagon-like peptide-2 (GLP-2) and glucose-dependent insulinotropic polypeptide (GIP) in 8 patients with type 1 diabetes mellitus (T1DM) without paracrine intraislet influence of insulin (C-peptide negative following a 5 g intravenous arginine stimulation: on study days only treated with basal insulin substitution) On 3 study days, 180-minute two-step glucose clamps were performed. Plasma glucose (PG) was clamped at fasting values, with a mean of 74 +/- 05 mM in the first 90 min (period 1) and raised 1.5 times the fasting values to a mean of 11.1 +/- 0 1 mM in the last 90 min (period 2) In randomised order either GIP, GLP-2. or saline were infused intravenously during first 50 min in both periods at rates designed to mimic postprandial hormone responses The resulting incremental area under curve values of glucagon were in period 1-38 +/- 44 (GIP), 120 +/- 48 (GLP-2), and -16 +/- 61 (saline) pM x 90 min (p = 0.087), respectively, and in period 2-157 +/- 76, 135 +/- 52, and -77 +/- 77 pM x 90 min (p = 0019), respectively Post hoc analysis showed significant differences only between the GLP-2 days versus the GIP and saline days In conclusion, GLP-2, but not GIP, was found to stimulate the release of glucagon in patients with T1DM, suggesting a role for GLP-2 in the postprandial hyperglucagonaemia characterising individuals with T1DM (C) 2010 Elsevier B.V. All rights reserved