The union of the state:: Myoclonic twitching is coupled with nuchal muscle atonia in infant rats
The union of the state:: Myoclonic twitching is coupled with nuchal muscle atonia in infant rats
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DOI：
10.1037//0735-7044.116.5.912
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发表时间：
2002-10-01
影响因子：
1.9
通讯作者：
Blumberg, MS
中科院分区：
文献类型：
--
作者：
Karlsson, KAE;Blumberg, MS
主动睡眠（AS），如肌阵挛性抽搐（MT）的发生所测量的，是新生大鼠中最普遍的行为状态。从历史上看，AS一直被认为是REM睡眠的发展前兆，但最近这一想法受到了质疑。在目前的研究中，作者评估，在2日龄，5日龄和8日龄的大鼠，MT和颈肌张力，REM睡眠的一个被广泛认可的组成部分之间的关系。在所有年龄段，肌张力减弱先于MT，并持续到出现清醒行为。此外，在从清醒行为到抽搐的过渡过程中，肌肉张力逐渐下降。因此，婴儿期的MT发生在肌肉张力不足的背景下，这一结果与AS是REM睡眠发育前体的观点一致。
Active sleep (AS), as measured by the occurrence of myoclonic twitching (MT), is the most prevalent behavioral state in newborn rats. Historically, AS has been considered a developmental precursor of REM sleep, but recently this idea has been questioned. In the present study, the authors assess, in 2-, 5-, and 8-day-old rats, the relationship between MT and nuchal muscle atonia, a widely recognized component of REM sleep. At all ages, muscle atonia preceded MT and persisted until awake behaviors occurred. In addition, muscle tone decreased gradually during transitions from awake behavior to twitching. Thus, MT during infancy occurs against a backdrop of muscle atonia, a result that is consistent with the view that AS is a developmental precursor of REM sleep.