Hypertriglyceridemia and hypoalphalipoproteinemia in azoospermic and oligospermic young men: relationships of endogenous testosterone to triglyceride and high density lipoprotein cholesterol metabolism.
Hypertriglyceridemia and hypoalphalipoproteinemia in azoospermic and oligospermic young men: relationships of endogenous testosterone to triglyceride and high density lipoprotein cholesterol metabolism.
复制标题
无精子症和少精子症年轻男性的高甘油三酯血症和低α脂蛋白血症：内源性睾酮与甘油三酯和高密度脂蛋白胆固醇代谢的关系。
DOI：
10.1016/0026-0495(81)90184-0
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Glueck,CJ
中科院分区：
文献类型：
--
作者：
Mendoza,SG;Osuna,A;Zerpa,A;Gartside,PS;Glueck,CJ
Based upon the hypothesis that endogenous testosterone plays a significant role in triglyceride and high density lipoprotein cholesterol metabolism, the specific aim of this study in 9 azoospermic and 10 oligospermic subjects (compared to 20 fertile men) was to examine potential relationships between endogenous testosterone, luteinizing hormone, follicle stimulating hormone, lipids-lipoproteins, and lipoprotein lipases. The azoospermic and oligospermic men had much higher fasting plasma triglyceride levels (mean ± SD; 479 ± 258, 295 ± 119) than did normal controls (105 ± 31 mg/dl,p< 0.001,p< 0.001). The azoospermic and oligospermic subjects also had much lower mean high density lipoprotein cholesterol levels (C-HDL) than normals (27 ± 8 and 29 ± 7 versus 44 ± 7 mg/dl,p< 0.001,p< 0.001). Very low density lipoprotein's (VLDL) in vitro potency to activate lipoprotein lipase (U/mg of VLDL protein) was about one-third normal in the azoospermic subjects (57 ± 26 U/mg), and about one-half normal in the oligospermic subjects (86 ± 27), with values in the normals being 167 ± 58,p< 0.001,p< 0.001. Mean plasma testosterone levels were 3.4 ± 0.7 ng/ml in the azoospermic subjects, considerably lower than mean levels in normals (6.6 ± 2.0,p< 0.001), with intermediate levels in the oligospermic men (5.2 ± 1.7 ng/ml). Pooling the data for the azoospermic, oligospermic, and normal men, plasma testosterone levels were positively correlated with C-HDL (r= .42,p< 0.01) and inversely correlated with triglyceride (r= −.50,p< 0.001) and very low density lipoprotein cholesterol (r= −.37,p< 0.02). Plasma testosterone was also positively correlated with lipoprotein lipase activator potency, (r= .45,p< 0.01). These findings suggest that endogenous physiologic testosterone levels may play a role relative to regulation of triglyceride and C-HDL levels in men, and may also affect the hydrolytic susceptability of very low density lipoprotein molecules. Hypertriglyceridemia and low C-HDL levels in azoospermic and oligospermic men mandate quantitation of lipid-lipoprotein levels in infertility clinics to identify men at putatively increased risk for future coronary heart disease.
