Seroprevalence of vaccine-preventable diseases among children and adolescents in Singapore: Results from the National Paediatric Seroprevalence Survey 2018
Seroprevalence of vaccine-preventable diseases among children and adolescents in Singapore: Results from the National Paediatric Seroprevalence Survey 2018
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DOI：
10.1016/j.ijid.2019.12.015
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发表时间：
2020-03-01
影响因子：
8.4
通讯作者：
Lee, Vernon Jian Ming
中科院分区：
文献类型：
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作者：
Ng, Yixiang;Chua, Lily Ai Vee;Lee, Vernon Jian Ming
目的：新加坡卫生部（MOH）进行了2018年全国儿科血清阳性率调查（NPSS 2018）估计新加坡儿童和青少年对麻疹、风疹、水痘、白喉、破伤风和B型肝炎的最新免疫水平，以及慢性B型肝炎病毒（HBV）携带的血清阳性率。方法：这项调查涉及从两家公立急症医院的1，200名1-17岁儿童和青少年中前瞻性收集残留血清。采用酶联免疫吸附试验（EIA）或鼠疫还原中和试验（PRNT）检测疫苗可预防疾病的血清阳性率。结果：新加坡1-17岁儿童和青少年麻疹和风疹抗体的总患病率为98.2%（95% CI：91.2-98.8%）和94.8%（95% CI：93.4-95.9%）。97.1%（95%CI：96.0-97.9%）的受试者至少对白喉有基本保护，而89.3%（95%CI：87.5-91.0%）的受试者对破伤风有保护。慢性HBV携带率为0.4%（95% CI：0.2-1.0%），而HBV免疫率为45.7%（95% CI：42.9-48.5%）。水痘抗体阳性率为52.9%（95%CI：50.1-55.7%），麻疹、风疹、白喉、破伤风抗体阳性率与疫苗接种情况一致。结论：新加坡的儿童和青少年对麻疹、风疹、白喉和破伤风有很好的预防。应继续努力确保高疫苗接种覆盖率。(C)2019年，任作家。由Elsevier Ltd代表国际传染病学会出版。
Objectives: The Ministry of Health (MOH), Singapore, conducted the National Paediatric Seroprevalence Survey 2018 (NPSS 2018) to estimate the latest immunity levels against measles, rubella, varicella, diphtheria, tetanus and hepatitis B, and the seroprevalence of chronic hepatitis B virus (HBV) carriage in children and adolescents in Singapore.Methods: The survey involved prospective collection of residual sera from 1,200 children and adolescents aged 1-17 years in two public acute hospitals. Enzyme-linked immunosorbent assays (EIA) or plague reduction neutralisation tests (PRNT) were used to determine the seroprevalence of the vaccine-preventable diseases.Results: Overall prevalence of measles and rubella antibodies among Singaporean children and adolescents aged 1-17 years were 98.2% (95% CI: 91.2-98.8%) and 94.8% (95% CI: 93.4-95.9%) respectively. 97.1% (95% CI: 96.0-97.9%) of subjects had at least basic protection against diphtheria, while 89.3% (95% CI: 87.5-91.0%) were protected against tetanus. The prevalence of chronic HBV carriage was 0.4% (95% CI: 0.2-1.0%), while 45.7% (95% CI: 42.9-48.5%) were immune against HBV. The seroprevalence for varicella antibodies was 52.9% (95% CI: 50.1-55.7%).Concordance between vaccination status and seroprevalence was observed for measles, rubella, diphtheria and tetanus. Conclusion: Singapore's children and adolescents are well-protected against measles, rubella, diphtheria and tetanus. Continual efforts in ensuring high vaccination coverage should be sustained. (C) 2019 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.