Treatment regimens for non-alcoholic fatty liver disease
Treatment regimens for non-alcoholic fatty liver disease
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DOI：
10.1016/s1665-2681(19)31827-7
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发表时间：
2009-01-01
影响因子：
3.8
通讯作者：
Younossi, Zobair M.
中科院分区：
文献类型：
--
作者：
Lam, Brian P.;Younossi, Zobair M.
随着肥胖和糖尿病的日益流行，代谢综合征及其相关的肝脏表现，非酒精性脂肪性肝病（NAFLD）受到了更多的关注。在被称为NAFLD的临床病理学病症范围内，只有少数患者具有非酒精性脂肪性肝炎（NASH）的组织学特征，其有可能进展为肝硬化和肝细胞癌。因此，诊断和治疗应针对NASH患者。目前的治疗建议包括减肥和逆转代谢综合征的其他成分，但其他几种治疗方式正在研究中。迄今为止，没有可靠的药物治疗显示对NASH有效。本文综述了所有可用的治疗方式，包括生活方式的改变，减肥手术，减肥药物，胰岛素增敏剂，降脂剂，抗氧化剂，细胞保护剂，和其他新的治疗方法。
With the growing epidemic of obesity and diabetes, more attention has been placed on metabolic syndrome and its associated hepatic manifestation, non-alcoholic fatty liver disease (NAFLD). Within the spectrum of clinico-pathologic conditions known as NAFLD, only a minority of patients has the histological features characteristic of non-alcoholic steatohepatitis (NASH), which has the potential to progress to cirrhosis and hepatocellular carcinoma. Therefore, diagnosis and therapy should target patients with NASH. Current treatment recommendations include weight loss and the reversal of other components of metabolic syndrome, but several other treatment modalities are under investigation. To date, no pharmacologic treatment has been reliably shown to be effective for NASH. This article reviews all available treatment modalities, including lifestyle changes, bariatric surgery, weight loss medications, insulin sensitizers, lipid lowering agents, antioxidants, cytoprotective agents, and other novel treatments.