Porokeratosis and cutaneous malignancy - A review
Porokeratosis and cutaneous malignancy - A review
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DOI：
10.1111/j.1524-4725.1996.tb00327.x
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发表时间：
1996-04-01
影响因子：
2.4
通讯作者：
Krain, AD
中科院分区：
文献类型：
--
作者：
Sasson, M;Krain, AD
背景。角化症是一种表皮角化疾病，临床表现为边缘凸起，组织学表现为角膜片状。虽然皮肤恶性肿瘤已报道出现在毛孔角化症，风险仍然未知。在过去，它被认为与放射治疗史有关。本研究的目的是估计在骨质疏松症中发生皮肤恶性肿瘤的频率，并确定哪些患者的风险最高。我们回顾了近30年来英语文献中的所有病例。281例病例中有21例（7.5%）在骨质疏松症中发现恶性肿瘤。大的病变、持续时间长的病变和线性型的风险最大。放射治疗是一个很少被发现的危险因素。角化症是一种恶性前病变，某些患者群体发生恶性转化的风险最大。
BACKGROUND. Porokeratosis is a disorder of epidermal keratinization manifested clinically by a raised border and histologically by a cornoid lamella. While cutaneous malignancy has been reported to arise in porokeratosis, the risk remains unknown. In the past it has been associated with a history of radiation therapy.OBJECTIVE. The purpose of this study is to estimate the frequency of cutaneous malignancy arising in porokeratosis and define those patients who are at highest risk.METHODS. All cases in the English language literature in the last 30 years were reviewed.RESULTS. Twenty-one (7.5%) of 281 cases reported revealed a malignancy arising within porokeratosis. Large lesions, those of long-standing duration, and the linear type were at greatest risk. Radiation therapy was an infrequently identified risk factor.CONCLUSION. Porokeratosis is a premalignant condition, with certain groups of patients at greatest risk for malignant transformation.