TGF-beta and osteoarthritis.
TGF-beta and osteoarthritis.
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DOI：
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发表时间：
2007
影响因子：
7
通讯作者：
E. B. Blaney Davidson;P. M. van der Kraan;W. B. van den Berg
中科院分区：
文献类型：
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作者：
E. B. Blaney Davidson;P. M. van der Kraan;W. B. van den Berg
目的骨关节炎（OA）的主要问题是软骨损伤。生长因子如转化生长因子-β（TGF-β）在软骨修复中具有巨大的潜力。在这篇综述中，我们将重点关注TGF-β对OA的潜在治疗干预、生长因子TGF-β在软骨修复中的应用以及TGF-β治疗可能发生的副作用。方法：本综述总结了2006年11月之前在PubMed数据库中发表的同行评议文章。此外，这篇综述补充了我们自己的小组在使用TGF-β作为软骨修复因子在OA的最新数据。结果TGF-β对软骨的维持至关重要，但缺乏OA样改变的结果。此外，TGF-β补充剂可以增强软骨修复，因此是一种潜在的治疗工具。然而，TGF-β补充剂的应用在关节的其他组织中提供了问题，并导致纤维化和骨赘形成。这可以通过在不需要的副作用部位局部抑制TGF-β或通过阻断对诱导纤维化或骨赘形成重要的TGF-β下游介质来克服。结论目前对TGF-β的了解表明，它对软骨的完整性至关重要，是预防或修复软骨损伤的有力工具。TGF-β补充剂的副作用可以通过局部抑制TGF-β本身或下游介质来克服。
OBJECTIVE Cartilage damage is a major problem in osteoarthritis (OA). Growth factors like transforming growth factor-beta (TGF-beta) have great potential in cartilage repair. In this review, we will focus on the potential therapeutic intervention in OA with TGF-beta, application of the growth factor TGF-beta in cartilage repair and on the side effects of TGF-beta treatment that could occur. METHODS This review summarizes peer-reviewed articles published in the PubMed database before November 2006. In addition, this review is supplemented with recent data of our own group on the use of TGF-beta as a cartilage reparative factor in OA. RESULTS TGF-beta is crucial for cartilage maintenance and lack there of results in OA-like changes. Moreover, TGF-beta supplementation can enhance cartilage repair and is therefore a potential therapeutic tool. However, application of TGF-beta supplementation provides problems in other tissues of the joint and results in fibrosis and osteophyte formation. This can potentially be overcome by local inhibition of TGF-beta at sites of unwanted side-effects or by blocking downstream mediators of TGF-beta that are important for the induction of fibrosis or osteophyte formation. CONCLUSION Current understanding of TGF-beta suggests that it essential for cartilage integrity and that it is a powerful tool to prevent or repair cartilage damage. The side-effects that occur with TGF-beta supplementation can be overcome by local inhibition of TGF-beta itself or downstream mediators.