Effect of Sodium Dodecyl Sulfate on the Continuous Crystallization in Microfluidic Devices Using Microbubbles
Effect of Sodium Dodecyl Sulfate on the Continuous Crystallization in Microfluidic Devices Using Microbubbles
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DOI：
10.1002/ceat.201900172
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发表时间：
2019-07
影响因子：
2.1
通讯作者：
Naghmeh Fatemi;Cedric Devos;Glenn De Cordt;T. Gerven;S. Kuhn
中科院分区：
文献类型：
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作者：
Naghmeh Fatemi;Cedric Devos;Glenn De Cordt;T. Gerven;S. Kuhn
在用于连续结晶的微反应器中引入微气泡增加了成核速率并且还防止了堵塞。添加表面活性剂影响微泡的产生，因为它减小了它们的尺寸，增加了它们的形成频率，因此也增加了每单位体积反应器的界面面积作为成核的非均相表面。在这里，十二烷基硫酸钠（SDS）对微泡生成和对乙酰氨基酚的连续结晶的影响进行了研究。据观察，虽然SDS显着扩大了可用于成核的异质表面，结晶本身被抑制其存在。
Introducing microbubbles in a microreactor for continuous crystallization increases the nucleation rate and also prevents clogging. Adding surfactants affects the microbubble generation as it reduces their size, increases their frequency of formation and consequently also the interfacial area per unit volume of reactor acting as heterogeneous surface for nucleation. Here, the effect of sodium dodecyl sulfate (SDS) on both the microbubble generation and the continuous crystallization of paracetamol is investigated. It is observed that while SDS significantly enlarges the heterogeneous surface available for nucleation, the crystallization itself is inhibited by its presence.