Development of a subject-specific guide system for Low-Intensity Focused Ultrasound (LIFU) brain stimulation
Development of a subject-specific guide system for Low-Intensity Focused Ultrasound (LIFU) brain stimulation
复制标题
低强度聚焦超声（LIFU）脑刺激特定学科导向系统的开发
DOI：
10.1016/j.cmpb.2019.05.001
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发表时间：
2019-07
影响因子：
6.1
通讯作者：
Haeyoung Joe;K. Pahk;Shinsuk Park;Hyungmin Kim
中科院分区：
文献类型：
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作者：
Haeyoung Joe;K. Pahk;Shinsuk Park;Hyungmin Kim
近年来，低强度聚焦超声(LIFU)被认为是一种很有前途的神经调节技术，因为它可以以高空间分辨率对大脑进行无创刺激。随着空间分辨率的提高，人们对开发更准确和更方便的导航系统的需求越来越大。因此，在本研究中，我们开发并制作了一种3D打印可穿戴对象专用头盔，用于理府刺激，保证了头盔的准确性。利用传统的图像导航系统，比较了目标位置与换能器声压半高全宽(FWHM)即焦体积的空间关系。根据位置误差的分布，目标位置很好地定位在焦体积内。
Low-Intensity Focused Ultrasound (LIFU) has recently been considered as a promising neuromodulation technique because it can noninvasively stimulate the brain with a high spatial resolution. As spatial resolution is improved, there is a growing demand for developing more accurate and convenient guide systems. Therefore, in the present study, we have developed and prototyped a 3D printed wearable subject-specific helmet for LIFU stimulation that is guaranteed to be accurate. The spatial relationship between the target position and the full-width at half-maximum (FWHM) of acoustic pressure of the transducer, i.e. focal volume, was compared using the conventional image-guided navigation system. According to the distribution of positional errors, the target position was located well within the focal volume.