Quality of life and psychological symptoms for women with bipolar disorder - a comparison between reproductive, menopause transition and post-menopause phases
Quality of life and psychological symptoms for women with bipolar disorder - a comparison between reproductive, menopause transition and post-menopause phases
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DOI：
10.1016/j.maturitas.2020.09.002
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发表时间：
2021-01-01
期刊：
影响因子：
4.9
通讯作者：
Perz, Janette
中科院分区：
文献类型：
--
作者：
Perich, Tania;Ussher, Jane;Perz, Janette
目的：更年期过渡可能与双相情感障碍女性的症状增加有关;然而，很少有人探讨这与其他生殖阶段的比较。本研究的目的是比较妇女在生殖，绝经过渡期和绝经后阶段的生活质量和心理症状与双相disorder.Study design相关的措施：妇女与双相情感障碍参加了一个大型的国际在线调查，并被归类为生殖阶段使用的ESTA和莫纳什标准。498名参与者被分为三组：育龄组202人（41%），绝经过渡组101人（20%），绝经后组195人（39%）。更年期评定量表（MRS）、抑郁焦虑和压力量表-21（DASS-21），结果：绝经过渡期组患者的生活质量（BD-QoL）显著低于其他各组，且绝经过渡期组患者在过去一年中更容易报告持续抑郁。焦虑是显着较高的更年期过渡和绝经后组相比，生育年龄group.Conclusions：生活质量和抑郁症的影响，更年期过渡的女性双相情感障碍。然而，焦虑可能是绝经后和绝经过渡期妇女的临床问题。需要研究来确定双相情感障碍女性在生殖生命周期中的症状如何变化，以及是否有针对性的治疗可能有所帮助。
Objective: The menopause transition may be associated with increased symptoms for women living with bipolar disorder; however, few have explored how this compares with other reproductive phases. The aim of this study was to compare women at reproductive, menopause transition and post-menopause phases on measures of quality of life and psychological symptoms associated with bipolar disorder.Study design: Women with bipolar disorder took part in a large international survey conducted online and were categorised into reproductive stages using the STRAW and Monash criteria. The 498 participants were divided into three groups: 202 (41%) in the reproductive age group, 101 (20%) in the menopause transition group and 195 (39%) in the post-menopause group.Main outcome measures: The Menopause Rating Scale (MRS), the Depression Anxiety and Stress Scales - 21 (DASS-21), the Altman Mania Rating Scale (ASRM) and the Bipolar Disorder Quality of Life scale (BD-QoL).Results: BD-QoL scores were significantly lower in the menopause transition group than in the other groups and that group was more likely to report being constantly depressed over the past year than the other groups. Anxiety was significantly higher in the menopause transition and post-menopause groups compared with the reproductive age group.Conclusions: Quality of life and depression are impacted by the menopause transition for women with bipolar disorder. However, anxiety may be a clinical issue for women in both the post-menopause and the menopause transition phases. Research is needed to determine how symptoms vary across the reproductive life cycle for women with bipolar disorder and if targeted treatments may assist.