Lesion growth and degeneration patterns measured using diffusion tensor 9.4-T magnetic resonance imaging in rat spinal cord injury Presented at the 2009 Joint Spine Section Meeting Laboratory investigation
Lesion growth and degeneration patterns measured using diffusion tensor 9.4-T magnetic resonance imaging in rat spinal cord injury Presented at the 2009 Joint Spine Section Meeting Laboratory investigation
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DOI：
10.3171/2010.3.spine09523
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发表时间：
2010-08-01
影响因子：
2.8
通讯作者：
Kurpad, Shekar N.
中科院分区：
文献类型：
--
作者：
Ellingson, Benjamin M.;Schmit, Brian D.;Kurpad, Shekar N.
object.利用扩散张量磁共振成像，作者进行了一项研究，探讨病变的生长和变性模式，从急性到慢性阶段的脊髓损伤（SCI），在一个实验动物模型。采用9.4 T磁共振成像系统，模拟人类脊髓损伤从急性期到慢性期的进展，对创伤性挫伤后2周至25周恢复的大鼠进行体内和离体扩散张量成像。结果显示，创伤性病变的显着增长，伤后15周，其中的大小和平均扩散率（MD）达到最大值，并保持通过其余的恢复。平均扩散率是敏感的整体脊髓完整性，而分数各向异性表现出特异性的空洞形成的网站。使用MD等高线图的体内数据和三维表面图的离体数据，显示MD作为一个函数的头-尾距离和恢复时间，允许文件的头和尾的病变扩散。结论。本研究的结果表明，病变形态和扩散率的变化超出了先前报告的时间点，并提供了一个独特的视角，在创伤性SC 1后的空腔形成和变性的过程。此外，结果表明，MD更准确地定义区域的组织损伤比T2信号高强度的区域。这可能对SCI中创伤后注射器的检测和潜在治疗具有重要的临床意义。(DOI：10.3171/2010.3.SPINE09523）
Object. Using diffusion tensor MR imaging, the authors conducted a study to explore lesion growth and degeneration patterns, from the acute through chronic stages of spinal cord injury (SCI), in an experimental animal model.Methods. In vivo and ex vivo diffusion tensor imaging was performed using a 9.4-T MR imaging system in rats allowed to recover from traumatic contusion SCI from 2 weeks through 25 weeks postinjury, mimicking progression of human SCI from the acute through chronic stages.Results. Results showed significant growth of the traumatic lesion up to 15 weeks postinjury, where both the size and mean diffusivity (MD) reached a maximum that was maintained through the remainder of recovery. Mean diffusivity was sensitive to overall spinal cord integrity, whereas fractional anisotropy showed specificity to sites of cavity formation. The use of an MD contour map for in vivo data and a 3D surface map for ex vivo data, showing MD as a function of rostral-caudal distance and recovery time, allowed documentation of rostral and caudal spreading of the lesion.Conclusions. Results from this study demonstrate changes in both lesion morphology and diffusivity beyond previously reported time points and provide a unique perspective on the process of cavity formation and degeneration following traumatic SC1. Additionally, results suggest that MD more accurately defines regions of histological damage than do regions of T2 signal hyperintensity. This could have significant clinical implications in the detection and potential treatment of posttraumatic syringes in SCI. (DOI: 10.3171/2010.3.SPINE09523)