Birthweight, early environment, and genetics:: a study of twins discordant for acute myocardial infarction
Birthweight, early environment, and genetics:: a study of twins discordant for acute myocardial infarction
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DOI：
10.1016/s0140-6736(00)05111-4
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发表时间：
2001-06-23
期刊：
影响因子：
168.9
通讯作者：
Lichtenstein, P
中科院分区：
文献类型：
--
作者：
Hübinette, A;Cnattingius, S;Lichtenstein, P
背景：流行病学研究表明，出生体重作为胎儿生长的粗略标志，低出生体重与冠心病风险增加有关。通过研究同性双胞胎之间的这种关联，可以大大减少遗传和早期环境因素的混杂。我们进行了一项病例对照研究，在双胞胎不一致的急性心肌梗死（AMI）。方法的病例对照研究嵌套在人口为基础的瑞典双胞胎登记处，并与国家死因和出院登记处。我们人工检索了包含132对AMI不一致的同性双胞胎和118对单独匹配的对照双胞胎的出生和母亲特征信息的出生记录。（平均2556 [SD 500] vs 2699 [530] g，p=0.04）、出生身长（47.1 [2.8] vs 47.9 [2.7] cm，p=0.04）和头围（33.0 [1.8] vs 33.5 [2.0] cm，p=0.03）。在AMI病例和健康双胞胎的配对比较中，没有发现出生测量的显著差异（出生体重2458 [510] vs 2534 [530] g，p=0.73;出生身长47.1[2.8] vs 47.2 [2.8] cm，p=0.91;头围33.0 [1.7] vs 33.0 [1.8] cm，p=0.92）。解释在双胞胎中出生特征和AMI之间缺乏相关性提示先前报道的相关性可能受遗传和早期环境因素的影响，或者可能。这些因素与出生体重无关。
Background Epidemiological studies that used birthweight as a crude marker of fetal growth have suggested that low birthweight is associated with increased risk of coronary heart disease. Through investigation of this association within same-sexed twin pairs, confounding by genetic and early environmental factors can be greatly decreased. We undertook a case-control study in twins discordant for acute myocardial infarction (AMI).Methods The case-control study was nested within the population-based Swedish Twin Registry and linked with the national cause-of-death and hospital-discharge registries. We manually retrieved birth records containing information on birth and maternal characteristics for 132 same-sexed twin pairs discordant for AMI and 118 individually matched control twin pairs.Findings In comparisons between AMI cases and external matched control twins, cases had significantly lower birthweight (mean 2556 [SD 500] vs 2699 [530] g, p=0.04), birth length (47.1 [2.8] vs 47.9 [2.7] cm, p=0.04), and head circumference (33.0 [1.8] vs 33.5 [2.0] cm, p=0.03) than controls. In within-pair comparisons between AMI cases and healthy co-twins, no significant differences in birth measurements were found (birthweight 2458 [510] vs 2534 [530] g, p=0.73; birth length 47.1[2.8] vs 47.2 [2.8] cm, p=0.91; head circumference 33.0 [1.7] vs 33.0 [1.8] cm, p=0.92).Interpretation The lack of an association between birth characteristics and AMI within twin pairs suggests that previously reported associations may be influenced by genetic and early environmental factors, or possibly. by unmeasured maternal factors that operate independently of birthweight.