Clinical features of 1487 COVID-19 patients with outpatient management in the Greater Paris: the COVID-call study
Clinical features of 1487 COVID-19 patients with outpatient management in the Greater Paris: the COVID-call study
复制标题
DOI：
10.1007/s11739-020-02379-z
复制
发表时间：
2020-05-30
影响因子：
4.6
通讯作者：
Adnet, Frederic
中科院分区：
文献类型：
--
作者：
Lapostolle, Frederic;Schneider, Elodie;Adnet, Frederic
COVID-19的临床特征主要在有和没有ICU入院的住院患者中描述。然而，高达80%的患者在门诊接受治疗。这一群体的记录很少。在法国，卫生当局建议对出现轻度至中度COVID-19症状的患者进行门诊管理。本研究的目的是描述其临床特征。这项研究在位于大巴黎地区的一个紧急医疗调度中心进行。根据WHO定义，本次调查中纳入的患者符合确诊的COVID-19感染标准。我们调查了临床特征，并将症状分类为全身症状、消化症状、耳鼻咽喉症状、胸部症状和眼部疾病。患者入选时间为2020年3月24日至4月6日。1487例患者包括：700例（47%）男性和752例（51%）女性，中位年龄为44（32-57）岁。除90%以上病例报告的干咳和发热外，最常见的症状是全身症状：身体疼痛/肌痛（N = 845; 57%），头痛（N = 824; 55%）和虚弱（N = 886; 60%）;呼吸短促（N = 479; 32%）和耳鼻咽喉症状，如嗅觉丧失（N = 415; 28%）和味觉丧失（N = 422; 28%）。320例（21%）病例报告胸痛，41例（3%）病例报告咯血。男性和女性患者之间的主要差异是女性患者的耳鼻咽喉症状以及腹泻，胸痛和头痛的患病率增加。在出现轻至中度症状的COVID-19患者中，全身症状和耳鼻咽喉症状占主导地位。呼吸急促和胸痛非常频繁。
Clinical features of COVID-19 have been mostly described in hospitalized patients with and without ICU admission. Yet, up to 80% of patients are managed in an outpatient setting. This population is poorly documented. In France, health authorities recommend outpatient management of patients presenting mild-to-moderate COVID-19 symptoms. The aim of this study was to describe their clinical characteristics. The study took place in an emergency medical dispatching center located in the Greater Paris region. Patients included in this survey met confirmed COVID-19 infection criteria according to the WHO definition. We investigated clinical features and classified symptoms as general, digestive, ear-nose-throat, thoracic symptoms, and eye disease. Patients were included between March 24 and April 6 2020. 1487 patients included: 700 (47%) males and 752 (51%) females, with a median age of 44 (32-57) years. In addition to dry cough and fever reported in more than 90% of cases, the most common symptoms were general symptoms: body aches/myalgia (N = 845; 57%), headache (N = 824; 55%), and asthenia (N = 886; 60%); shortness of breath (N = 479; 32%) and ear-nose-throat symptoms such as anosmia (N = 415; 28%) and ageusia (N = 422; 28%). Chest pain was reported in 320 (21%) cases and hemoptysis in 41 (3%) cases. The main difference between male and female patients was an increased prevalence of ear-nose-throat symptoms as well as diarrhea, chest pains, and headaches in female patients. General symptoms and ear-nose-throat symptoms were predominant in COVID-19 patients presenting mild-to-moderate symptoms. Shortness of breath and chest pain were remarkably frequent.