Role of fluorine-18 fluoro-deoxyglucose positron emission tomography scan in the evaluation and follow-up of patients with low-grade lymphomas
Role of fluorine-18 fluoro-deoxyglucose positron emission tomography scan in the evaluation and follow-up of patients with low-grade lymphomas
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DOI：
10.1002/cncr.21967
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发表时间：
2006-07-01
期刊：
影响因子：
6.2
通讯作者：
Nugent, Francis
中科院分区：
文献类型：
--
作者：
Karam, Maroun;Novak, Leon;Nugent, Francis
背景18氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）对非霍奇金淋巴瘤的分期具有很好的敏感性和特异性，但据作者所知，迄今为止很少有研究仅对低级别淋巴瘤进行FDG-PET评估。对活检证实的非转化和转化滤泡性淋巴瘤（FL）、B细胞小细胞淋巴细胞性淋巴瘤（SLL/CLL）或边缘区淋巴瘤（MZL）患者进行了回顾性研究，这些患者在3周内接受了PET和计算机断层扫描（CT）扫描。测量所有异常病灶的标准摄取值（SUV）。在FL中，PET表现出94%的敏感性和100%的特异性分期。PET在检测复发或评估治疗反应方面比CT更具特异性（91% vs. 50%）。WHO 1级、2级和3级疾病患者的FDG亲和力无显著差异（方差分析[ANOVA]）。对于MZL分期，PET具有中等敏感性（71%），在描述结节部位方面优于单独的CT（85% vs 57%敏感性）。在SLL/CLL中，PET的敏感性为53%，与CT相比，19例患者中有5例（26%）低估了疾病程度。PET不影响初始治疗，但证实了75%的患者疑似复发。未转化的FL具有更高的SUV（ANOVA，P
BACKGROUND. Fluorine-18 fluoro-deoxyglucose positron emission tomography (FDG-PET) scanning has excellent sensitivity and specificity for staging non-Hodgkin lymphomas, but to the authors' knowledge few studies to date have evaluated FDG-PET in low-grade lymphomas only.METHODS. A retrospective study was performed on patients with biopsy-proven nontransformed and transformed follicular lymphoma (FL), B-cell small-cell lymphocytic lymphoma (SLL/CLL), or marginal zone lymphoma (MZL) who underwent PET and computed tomography (CT) scans within 3 weeks. Standard uptake values (SUV) of all abnormal foci were measured.RESULTS. In FL, PET demonstrated 94% sensitivity and 100% specificity for staging. PET was more specific than CT for detecting recurrence or assessing therapeutic responses (91% vs. 50%). FDG avidity among patients with WHO Grades 1, 2, and 3 disease was not significantly different (analysis of variance [ANOVA]). For MZL staging, PET had moderate sensitivity (71%) and outperformed CT alone in the depiction of extranodal sites (85% vs. 57% sensitivity). In SLL/CLL, PET sensitivity was 53% and underestimated disease extent in 5 of 19 patients (26%) compared with CT. PET did not affect initial management but confirmed suspected recurrences in 75% of patients. Nontransformed FL had a higher SUV (ANOVA, P