Nasal natural killer (NK) cell lymphoma: report of a case with activated NK cells containing Epstein‐Barr virus and expressing CD21 antigen, and comparative studies of their phenotype and cytotoxicity with normal NK cells
Nasal natural killer (NK) cell lymphoma: report of a case with activated NK cells containing Epstein‐Barr virus and expressing CD21 antigen, and comparative studies of their phenotype and cytotoxicity with normal NK cells
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鼻自然杀伤（NK）细胞淋巴瘤：一例含有 Epstein-Barr 病毒并表达 CD21 抗原的活化 NK 细胞病例报告，及其与正常 NK 细胞的表型和细胞毒性的比较研究
DOI：
10.1111/j.1365-2141.1995.tb05303.x
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发表时间：
1995
影响因子：
6.5
通讯作者：
K. Oshimi
中科院分区：
文献类型：
--
作者：
T. Kaneko;Junko Fukuda;T. Yoshihara;Heng Zheng;S. Mori;H. Mizoguchi;K. Oshimi
摘要鼻腔恶性淋巴瘤一直被认为是T细胞的来源，但最近的表面标记研究表明，超过一半的淋巴瘤是来自自然杀伤（NK）细胞。在这里，我们描述了一个鼻淋巴瘤的情况下，淋巴瘤细胞被确定为NK细胞的形态，表型，免疫基因型和功能的研究。我们相信这是第一个有NK活性功能证据的研究。当与正常新鲜分离的NK细胞或活化的NK细胞相比时，患者肿瘤细胞的表面表型和NK活性是活化的NK细胞的表面表型和NK活性，而不是静息的NK细胞的表面表型和NK活性。此外，在肿瘤细胞中检测到爱泼斯坦-巴尔病毒（EBV），并且发现淋巴瘤细胞是单克隆扩增的。患者的淋巴瘤细胞还表达EBV受体CD 21（CR2）和CD 30（Ki-1），这些在正常NK细胞上尚未描述。因此，我们检查了正常供体的高度富集的NK细胞，并发现一些静息和/或活化的NK细胞表达这些抗原。
Summary. Malignant lymphomas arising from the nasal cavity have been considered to be derived from T cells, but recent surface marker studies suggest that more than half of the lymphomas are derived from natural killer (NK) cells. Here we describe a case of nasal lymphoma whose lymphoma cells were identified as NK cells by morphological, phenotypic, immunogenotypic, and functional studies. We believe this is the first study with functional evidence of NK activity. When compared with normal freshly isolated NK cells or activated NK cells, the surface phenotypes and NK activity of the patient tumour cells were those of the activated, but not resting, NK cells. Also, Epstein‐Barr virus (EBV) was detected in the tumour cells and the lymphoma cells were found to be monoclonally expanded. The patient's lymphoma cells also expressed EBV receptor CD21 (CR2) and CD30 (Ki‐1) that have not been described on normal NK cells. We therefore examined highly enriched NK cells of normal donors, and found that some resting and/or activated NK cells express these antigens.
部分外周 T 细胞淋巴瘤中不存在克隆性 β 和 γ T 细胞受体基因重排。
DOI：
--
发表时间：
1988
期刊：
The American journal of pathology
影响因子：
--
作者：
Weiss,LM;Picker,LJ;Grogan,TM;Warnke,RA;Sklar,J
通讯作者：
Sklar,J