Adult Height and Body Mass Index in Relation to Risk of Total Stroke and its Subtypes: The Circulatory Risk in Communities Study
Adult Height and Body Mass Index in Relation to Risk of Total Stroke and its Subtypes: The Circulatory Risk in Communities Study
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DOI：
10.1016/j.jstrokecerebrovasdis.2013.06.009
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发表时间：
2014-04-01
影响因子：
2.5
通讯作者：
Iso, Hiroyasu
中科院分区：
文献类型：
--
作者：
Shimizu, Yuji;Imano, Hironori;Iso, Hiroyasu
背景：一些研究报告称，基于身高是儿童身体状况的标志这一假设，身高和中风风险呈负相关。然而，有限的研究考虑了当前身体状况对身高和中风风险之间关系的影响。方法：我们对 12,222 名 40 至 69 岁的日本患者进行了一项前瞻性队列研究，对中风发生率进行系统监测。由于体重指数（BMI）被视为心血管风险当前身体状况的替代指标，因此我们根据BMI对该风险进行了分层分析。结果：在中位 17 年的随访期间，发生了 565 例中风（326 例缺血性中风和 186 例出血性中风），显示身高和中风风险之间呈负相关，与经典心血管危险因素无关。与最低身高组（女性 154 厘米）相比，男性为 0.70 (95% CI 0.49-1.00；P - .043)，女性为 0.44 (95% CI 0.27-0.70；P < .001)。当分析仅限于具有 BMI 的人时
Background: Several studies have reported that height and risk of stroke are inversely associated based on the hypothesis that height is a marker of childhood physical condition. However, a limited number of studies have taken account of the effect of current physical condition on the relationship between height and risk of stroke. Methods: We conducted a prospective cohort study of 12,222 40- to 69-year-old Japanese patients under systematic surveillance for stroke incidence. Because body mass index (BMI) is regarded as a surrogate marker of current physical condition for cardiovascular risk, we performed a stratified analysis of this risk based on BMI. Results: During the median 17-year follow-up, there were 565 incident strokes (326 ischemic and 186 hemorrhagic strokes) showing an inverse association between height and risk of stroke independent of classical cardiovascular risk factors. Compared with the lowest height group (154 cm for women) were 0.70 (95% CI 0.49-1.00; P - .043) for men and 0.44 (95% CI 0.27-0.70; P < .001) for women. When the analysis was restricted to those with BMI