Serum 2′-5′oligoadenylate synthetase as a monitoring marker of antiviral effect during interferon therapy for chronic type B hepatitis
Serum 2′-5′oligoadenylate synthetase as a monitoring marker of antiviral effect during interferon therapy for chronic type B hepatitis
复制标题
血清2′-5′寡腺苷酸合成酶作为干扰素治疗慢性乙型肝炎抗病毒效果的监测标志物
DOI：
10.1007/bf02774192
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Y. Okuuchi
中科院分区：
文献类型：
--
作者：
Y. Karino;T. Sugawara;A. Saga;J. Yoshida;T. Matsushima;T. Miyazaki;J. Toyota;Y. Okuuchi
本研究旨在探讨血清2 - 5-腺苷酸合成酶（2- 5 AS）活性测定在慢性B型肝炎患者IFN治疗中的临床意义。血清2-5AS活性在上述治疗过程中迅速升高，并在整个治疗期间维持在中等至高水平，尽管升高能力反映了个体差异。治疗过程中血清2-5AS活性变化与PBMCs 2-5AS活性变化基本一致。2-5AS活性与DNA-P呈负相关，即在血清2-5AS活性显著应答的患者中，干扰素治疗后DNA-P常从血清中消失。IFN治疗期间血清2-5AS活性的增强似乎与抗病毒活性的增加相关。结果表明，血清2- 5 AS活性测定是监测慢性B型肝炎患者干扰素治疗过程中抗病毒活性的一个有用的探针。
SummaryWe evaluated the usefulness of serum 2′–5′oligoadenylate synthetase (2–5AS) activity assay in monitoring the anti-viral activity of chronic type B hepatitis patients during IFN therapy. The serum 2–5AS activity was rapidly increased during the above therapy and was maintained at a medium-to-high level throughout the therapy period, although the capacity for increase reflected differences among individuals. The kinetics of serum 2–5AS activity during the therapy was almost consistent with that of the PBMCs 2–5AS activity. 2–5AS activity had an inverse correlation with DNA-P; i.e. DNA-P often disappeared from serum after interferon treatment in patients with a marked response in serum 2–5AS activity. The enhancement of serum 2–5AS activity during IFN therapy seemed to correlate with an increase in anti-viral activity. The results suggest that the serum 2–5AS activity assay is a useful probe for monitoring the anti-viral activity of chronic type B hepatitis patients during interferon therapy.