Oxytocin increases the pleasantness of affective touch and orbitofrontal cortex activity independent of valence
Oxytocin increases the pleasantness of affective touch and orbitofrontal cortex activity independent of valence
复制标题
催产素可增加情感触觉和眶额皮层活动的愉悦感，与价态无关
DOI：
10.1016/j.euroneuro.2020.08.003
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发表时间：
2020-10-01
影响因子：
5.6
通讯作者：
Yao, Shuxia
中科院分区：
文献类型：
--
作者：
Chen, Yuanshu;Becker, Benjamin;Yao, Shuxia
触摸在亲和行为和社交沟通中起着至关重要的作用。神经肽催产素会因触摸而释放，并可能起到促进社交触摸的奖励作用的作用。然而，迄今为止还没有研究确定催产素是否促进对非社会管理的情感触摸的行为或神经反应以及触摸价可能的差异效应。在一项功能性 MRI 实验中，我们对 40 名男性受试者使用随机安慰剂对照、受试者内设计，研究了鼻内催产素 (24IU) 对通过不同类型的材料以最佳刺激 C 纤维的频率对手臂进行正价、中性和负价触摸的行为和神经反应的影响。结果表明，催产素显着增加了触摸的愉悦感和眶额皮质的激活，与触摸效价无关。 OT 对触摸引起的眶额激活的影响也与血液中基础催产素浓度呈正相关。此外，前岛叶活动以及杏仁核和右前岛叶之间的功能连接仅在负价接触时才会增强。总体而言，本研究提供了第一个证据，表明催产素可以促进所有类型触摸的奖励效果，无论化合价如何。 (C) 2020 Elsevier B.V. 和 ECNP。版权所有。
Touch plays a crucial role in affiliative behavior and social communication. The neuropeptide oxytocin is released in response to touch and may act to facilitate the rewarding effects of social touch. However, no studies to date have determined whether oxytocin facilitates behavioral or neural responses to non-socially administered affective touch and possible differential effects of touch valence. In a functional MRI experiment using a randomized placebo-controlled, within-subject design in 40 male subjects we investigated the effects of intranasal oxytocin (24IU) on behavioral and neural responses to positive, neutral and negative valence touch administered to the arm via different types of materials at a frequency aimed to optimally stimulate C-fibers. Results showed that oxytocin significantly increased both the perceived pleasantness of touch and activation of the orbitofrontal cortex independent of touch valence. The effects of OT on touch-evoked orbitofrontal activation were also positively associated with basal oxytocin concentrations in blood. Additionally, anterior insula activity and the functional connectivity between the amygdala and right anterior insula were enhanced only in response to negative valence touch. Overall, the present study provides the first evidence that oxytocin may facilitate the rewarding effects of all types of touch, irrespective of valence. (C) 2020 Elsevier B.V. and ECNP. All rights reserved.