FAILURE OF 5-THIO-D-GLUCOSE TO ALTER CELL-SURVIVAL IN IRRADIATED OR UNIRRADIATED EMT6 TUMORS
FAILURE OF 5-THIO-D-GLUCOSE TO ALTER CELL-SURVIVAL IN IRRADIATED OR UNIRRADIATED EMT6 TUMORS
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DOI：
10.2307/3576416
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发表时间：
1984-01-01
影响因子：
3.4
通讯作者：
SCHULZ, RJ
中科院分区：
文献类型：
--
作者：
ROCKWELL, S;SCHULZ, RJ
使用体内的EMT6小鼠乳腺肿瘤以及细胞培养中的EMT6细胞对葡萄糖类似物5 - 硫代 - D - 葡萄糖（5TG）的抗肿瘤作用进行了测试。在体外，5TG选择性地杀死缺氧的EMT6细胞。然而，给患有EMT6肿瘤的小鼠施用5TG对未照射肿瘤的细胞没有产生明显的毒性，也没有改变照射肿瘤中细胞的存活率。在施用5TG之前让小鼠禁食以降低血糖浓度增加了药物对小鼠的毒性，但并没有使肿瘤得到更有效的治疗。这些数据没有提供证据表明5 - 硫代 - D - 葡萄糖无论是作为细胞毒性剂还是作为放射增敏剂都能有效地用于实体肿瘤的治疗。
The antineoplastic effects of the glucose analog 5-thio-D-glucose (5TG) were tested using EMT6 mouse mammary tumors in vivo and EMT6 cells in cell culture. In vitro, 5TG selectively killed hypoxic EMT6 cells. However, administration of 5TG to mice bearing EMT76 tumors produced no significant toxicity to the cells of unirradiated tumors and did not alter the survival of cells in irradiated tumors. Fasting the mice to lower blood glucose concentrations before administration of 5TG increased the toxicity of the drug to the mice, but did not allow more efficacious treatment of the tumors. The data provided no evidence that 5-thio-D-glucose can be used effectively for the treatment of solid tumors, either as a cytotoxic agent or as a radiosensitizer.