POLYMER INACCESSIBLE VOLUME CHANGES DURING OPENING AND CLOSING OF A VOLTAGE-DEPENDENT IONIC CHANNEL
POLYMER INACCESSIBLE VOLUME CHANGES DURING OPENING AND CLOSING OF A VOLTAGE-DEPENDENT IONIC CHANNEL
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DOI：
10.1038/323036a0
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发表时间：
1986-09-04
期刊：
影响因子：
64.8
通讯作者：
PARSEGIAN, VA
中科院分区：
文献类型：
--
作者：
ZIMMERBERG, J;PARSEGIAN, VA
渗透应力可用于估计电压门控离子通道打开和关闭期间的内部体积变化。来自大鼠肝脏和脉孢菌属的线粒体电压依赖性阴离子通道重建成平面脂质双层，显示出2至4倍的变化。104埃3，与阻塞或局部门控模型不一致的大变化，但支持通道空间主要闭合的模型。
Osmotic stress can be used to estimate the internal volume change during the opening and closing of a voltage gated ionic channel. Mitochondrial voltage-dependent anion channels, from rat liver and from Neurospora, reconstituted into planar lipid bilayers show a change of 2 to 4 .times. 104 .ANG.3 in internal volume, a large change inconsistent with a blocking or local gating model but supporting models with major closure of the channel space.