SERTOLI-CELL DIFFERENTIATION IN THE TESTES OF MICE GENETICALLY DEFICIENT IN GERM-CELLS
SERTOLI-CELL DIFFERENTIATION IN THE TESTES OF MICE GENETICALLY DEFICIENT IN GERM-CELLS
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DOI：
10.1095/biolreprod20.5.1031
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发表时间：
1979-01-01
影响因子：
3.6
通讯作者：
EPPIG, JJ
中科院分区：
文献类型：
--
作者：
HANDEL, MA;EPPIG, JJ
使小鼠缺乏生殖细胞的突变提供了一个自然的实验系统，用于研究没有正常数量生殖细胞的支持细胞的分化。使用了2个可行的突变体（无毛，at/at，和显性斑点，W/Wv）与睾丸严重缺乏生殖细胞，因为生殖嵴的失败，成为充分填充生殖细胞。这些小鼠青春期前睾丸的超微结构检查显示，支持细胞的成熟在结构和时间上基本正常。典型的三分核仁、支持细胞连接和线粒体分化正常。分化中的生殖细胞的正常补充不是支持细胞结构分化的先决条件。
Mutations rendering mice deficient in germ cells provide a natural experimental system for investigation of the differentiation of Sertoli cells without the normal number of germ cells. Use was made of 2 viable mutants (atrichosis, at/at, and dominant spotting, W/Wv) with testes grossly deficient in germ cells because of the failure of the genital ridges to become adequately populated with germ cells. Ultrastructural examination of prepuberal testes of such mice revealed that essentially normal, both structural and temporal, maturation of the Sertoli cells occurred. There was normal differentiation of the typical tripartite nucleolus, the Sertoli cell junctions and mitochondria. The normal complement of differentiating germ cells is not a prerequisite for structural differentiation of Sertoli cells.