Etiologic factors and clinical features of symptomatic epilepsy: Focus on pediatric cases
Etiologic factors and clinical features of symptomatic epilepsy: Focus on pediatric cases
复制标题
有症状癫痫的病因和临床特征：以儿科病例为中心
DOI：
10.1111/j.1440-1819.2004.01244_3.x
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发表时间：
2004
影响因子：
11.9
通讯作者：
H. Shigematsu
中科院分区：
文献类型：
--
作者：
T. Fujiwara;H. Shigematsu
本文根据383例癫痫住院患者的临床资料，从临床角度探讨了症状性癫痫的可能病因。 部分性癫痫的主要病因是颅内感染、脑畸形和围产期脑损伤。在全身性癫痫中，主要的假定病因是围产期脑损伤、颅内感染和脑畸形。部分性癫痫的推定病因中，额叶癫痫以脑畸形最多见，颞叶癫痫以初始惊厥状态最多见，枕叶癫痫以围产期脑损害最多见。婴儿期严重肌阵挛性癫痫是婴儿期最难治的癫痫综合征，其电临床特征是目前研究的热点，本文介绍了其遗传学研究的最新进展。
Abstract We discuss the presumptive etiologic factors of symptomatic epilepsy from the clinical standpoint, based on our experience of 383 inpatients with epilepsy, with a focus on children. The main (top three) presumptive etiologic factors in partial epilepsy are intracranial infection, cerebral malformation and perinatal brain damage. In generalized epilepsy, the main presumptive etiologic factors are perinatal brain damage, intracranial infection, and cerebral malformation. As regards presumptive etiologic factors in partial epilepsy, cerebral malformation was most common in frontal lobe epilepsy, initial convulsive status in temporal lobe epilepsy and perinatal brain damage in occipital lobe epilepsy. Electroclinical characteristics of severe myoclonic epilepsy in infancy, the most intractable epilepsy syndrome in infancy, is the focus and recent advances of genetic research are introduced.