SKELETAL-MUSCLE METABOLISM IN PATIENTS WITH MALIGNANT-TUMOR
SKELETAL-MUSCLE METABOLISM IN PATIENTS WITH MALIGNANT-TUMOR
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DOI：
10.1016/0014-2964(76)90036-0
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发表时间：
1976-01-01
影响因子：
8.4
通讯作者：
SCHERSTEN, T
中科院分区：
文献类型：
--
作者：
LUNDHOLM, K;BYLUND, AC;SCHERSTEN, T
从43名癌症患者和55名匹配的、可能是代谢健康的对照组的骨骼肌活检中，测定了酶活性、葡萄糖同化和代谢能力以及亮氨酸在蛋白质中的掺入率。在癌症患者的肌肉组织中，组织蛋白酶D和β-葡萄糖醛酸苷酶的溶酶体酶活性增加。酸性磷酸酶的活性与对照组的肌肉组织中相同。己糖激酶、磷酸果糖激酶、乳酸脱氢酶和细胞色素c氧化酶活性显著降低。这一下降伴随着葡萄糖C掺入糖原、乳酸和二氧化碳的比率下降。癌症患者亮氨酸掺入蛋白质的比率明显降低，蛋白质的部分降解率增加。氨基酸对亮氨酸掺入蛋白质的比率的刺激程度与对照组相同。癌症患者肌肉中的RNA浓度没有变化。结果提示，恶性肿瘤可引起宿主骨骼肌代谢的特异性改变。蛋白质的生物合成速度似乎降低了，而降解率却增加了。葡萄糖同化和新陈代谢能力下降，表明癌症患者肌肉的能量调节紊乱。
Skeletal muscle biopsies were taken from 43 cancer patients and 55 matched, presumably metabolically healthy controls for determinations of enzyme activities, capacity of glucose assimilation and metabolism and the incorporation rate of leucine into proteins. In muscle tissue from cancer patients the activities of the lysosomal enzymes, cathepsin D and .beta.-glucuronidase, were increased. Acid phosphatase activity was the same as in muscle tissue from controls. The activities of hexokinase, phosphofructokinase, lactate dehydrogenase and cytochrome c oxidase were significantly decreased. This decrease was accompanied by a decreased incorporation rate of glucose C into glycogen, lactate and CO2. The incorporation rate of leucine into proteins was significantly decreased in cancer patients and the fractional degradation rate of proteins was increased. Amino acids caused the same degree of stimulation on the leucine incorporation rate into proteins as in the controls. The RNA concentration was unchanged in muscles from cancer patients. The results suggest that malignant tumors provoke specific alterations of skeletal muscle metabolism of the host. The rate of protein biosynthesis seems to be decreased together with an increased degradation rate. The capacity for glucose assimilation and metabolism is decreased indicating a disturbed energy regulation in the muscles of cancer patients.