Evolution of evolvability in a developmental model
Evolution of evolvability in a developmental model
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DOI：
10.1111/j.1558-5646.2007.00303.x
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发表时间：
2008-02-01
期刊：
影响因子：
3.3
通讯作者：
Wagner, Guenter R.
中科院分区：
文献类型：
--
作者：
Draghi, Jeremy;Wagner, Guenter R.
进化性，即种群适应的能力，可以通过改变决定遗传变异的机制和发展过程而进化。在这里，我们构建和发展一个简单的发育模型，其中基因的多效性效应可以演变。我们证明，在不断变化的环境中的选择有利于一个特定的模式的变异性，这种青睐的模式最大限度地提高进化。我们的分析表明，进化能力较高的突变基因型更有可能增加固定。我们还表明，高度进化的基因型的人口是不太可能被入侵的突变体与较低的进化能力，这种动态主要形状的进化能力。我们研究了几个理论上的反对意见，根据这一结果的演化性的演变。我们还表明，这一结果是强大的重组的存在或不存在，并探讨如何非随机的环境变化可以选择一个模块化的变异模式。
Evolvability, the ability of populations to adapt, can evolve through changes in the mechanisms determining genetic variation and in the processes of development. Here we construct and evolve a simple developmental model in which the pleiotropic effects of genes can evolve. We demonstrate that selection in a changing environment favors a specific pattern of variability, and that this favored pattern maximizes evolvability. Our analysis shows that mutant genotypes with higher evolvability are more likely to increase to fixation. We also show that populations of highly evolvable genotypes are much less likely to be invaded by mutants with lower evolvability, and that this dynamic primarily shapes evolvability. We examine several theoretical objections to the evolution of evolvability in light of this result. We also show that this result is robust to the presence or absence of recombination, and explore how nonrandom environmental change can select for a modular pattern of variability.