In vivo evaluation of porous nanohydroxyapatite/polyamide 66 struts in a goat cervical fusion model
In vivo evaluation of porous nanohydroxyapatite/polyamide 66 struts in a goat cervical fusion model
复制标题
山羊颈椎融合模型中多孔纳米羟基磷灰石/聚酰胺-66笼的体内评估
DOI：
10.1038/s41598-020-65341-1
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发表时间：
2020-06-26
影响因子：
4.6
通讯作者：
Hu, Ning
中科院分区：
文献类型：
--
作者：
Liang, Xi;Li, Feilong;Hu, Ning
The hollow cylindrical nanohydroxyapatite/polyamide 66 strut (n-HA/PA66) has been used clinically for anterior cervical reconstruction. However, rates of occurrence of a "radiolucent gap" between the dense strut and adjacent endplates were reported. The aim of this in vivo study was to evaluate the viability and advantages of the novel porous n-HA/PA66 strut. The goat C3/4 partial discectomy and fusion model was built, and two groups of n-HA/PA66 struts were implanted into C3/4: group 1, porous n-HA/PA66 strut; and group 2, hollow cylindrical n-HA/PA66 strut filled with autogenous cancellous bone. CT evaluation was performed to assess the fusion status after 12 and 24 weeks. The cervical spines were harvested. Histomorphological analysis was performed to determine new bone formation. Biomechanical testing was performed to determine range of motion (ROM). CT confirmed the disappearance of the boundary of the porous strut and host bone, while the radiolucent gap remained clearly discernible in the dense strut group. The mean CT fusion scores of the porous group were significantly higher. Histologic evaluation showed that the porous struts promoted better osteointegration. Calcein fluorochrome labelling indicated faster bone ingrowth in the porous struts. Biomechanical tests revealed that the porous struts had significantly reduced micromotion. The porous n-HA/PA66 strut could offer interesting potential for cervical reconstruction after corpectomy.
