DbClustal: rapid and reliable global multiple alignments of protein sequences detected by database searches
DbClustal: rapid and reliable global multiple alignments of protein sequences detected by database searches
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DOI：
10.1093/nar/28.15.2919
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发表时间：
2000-08-01
影响因子：
14.9
通讯作者：
Poch, O
中科院分区：
文献类型：
--
作者：
Thompson, JD;Plewniak, F;Poch, O
DbClustal解决了通过数据库同源性搜索检测到的得分最高的全长序列自动多重比对这一重要问题。通过将局部比对算法和全局比对算法的优势结合到一个单一系统中，DbClustal能够对高度差异、复杂的序列集提供准确的全局比对。局部比对信息以序列对之间一系列锚点的形式被纳入到ClustalW全局比对中。该方法通过由Blast后处理程序Ballast提供的锚点进行了演示。DbClustal的快速性和可靠性已通过最近注释的深海火球菌蛋白质组得到证明，其中完全错位序列的比对数量从20%减少到……
DbClustal addresses the important problem of the automatic multiple alignment of the top scoring full-length sequences detected by a database homology search. By combining the advantages of both local and global alignment algorithms into a single system, DbClustal is able to provide accurate global alignments of highly divergent, complex sequence sets. Local alignment information is incorporated into a ClustalW global alignment in the form of a list of anchor points between pairs of sequences. The method is demonstrated using anchors supplied by the Blast post-processing program, Ballast. The rapidity and reliability of DbClustal have been demonstrated using the recently annotated Pyrococcus abyssi proteome where the number of alignments with totally misaligned sequences was reduced from 20% to