Human T-cell lymphotropic virus type III infection in a cohort of homosexual men in New York City.
Human T-cell lymphotropic virus type III infection in a cohort of homosexual men in New York City.
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DOI：
10.1001/jama.1986.03370160065028
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发表时间：
1986-04
期刊：
影响因子：
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通讯作者：
C. E. Stevens;P. E. Taylor;Edith A. Zang;John M. Morrison;Edward J. Harley;Santiago Rodríguez de Córdoba;Carlos Bacino;Robert C.Y. Ting;A. Bodner;M. Sarngadharan;Robert C. Gallo;Pablo Rubinstein
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文献类型：
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作者：
C. E. Stevens;P. E. Taylor;Edith A. Zang;John M. Morrison;Edward J. Harley;Santiago Rodríguez de Córdoba;Carlos Bacino;Robert C.Y. Ting;A. Bodner;M. Sarngadharan;Robert C. Gallo;Pablo Rubinstein
使用自1978年以来收集的血液样本，我们调查了获得性免疫缺陷综合征的病原人类t细胞淋巴细胞病毒III型（HTLV-III）的流行病学，研究对象是自获得性免疫缺陷综合征流行以来居住在纽约市的378名同性恋活跃男性。从1978年到1979年，血清中抗htlv - iii的患病率为6.6%，随后易感男性血清转换的年发病率在5.5%至10.6%之间。发病率最高的是近年来，尽管这些男性在这段时间的性活动有所减少。这些数据表明所研究的同性恋人群中HTLV-III感染的持续风险，并强调需要更有效地预防传播。抗体首次出现的年份是唯一确定的与抗体阳性男性细胞介导免疫改变相关的因素。在1981年或更早成为抗体阳性的男性目前的OKT4/OKT8比率明显低于最近血清转化的男性。需要进一步的后续行动来确定这种联系的原因。
Using blood samples collected since 1978, we investigated the epidemiology of human T-cell lymphotropic virus type III (HTLV-III), the etiologic agent of the acquired immunodeficiency syndrome, in a group of 378 homosexually active men who have resided in New York City since the acquired immunodeficiency syndrome epidemic began. The anti-HTLV-III prevalence was 6.6% in sera from 1978 or 1979, and the subsequent annual incidence of seroconversion among susceptible men ranged between 5.5% and 10.6%. The highest incidences were in recent years, even though these men reported a decrease in their sexual activity during this time. These data demonstrate the continuing risk of HTLV-III infections in the homosexual population studied and emphasize the need for more effective prevention of transmission. The year during which antibody was first present was the only factor identified that was associated with altered cell-mediated immunity in antibody-positive men. Men who became antibody positive in 1981 or earlier currently had significantly lower OKT4/OKT8 ratios than did those who seroconverted more recently. Further follow-up will be necessary to establish the reasons for this association.