Selective reduction of genioglossal muscle activity by alcohol in normal human subjects.
Selective reduction of genioglossal muscle activity by alcohol in normal human subjects.
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发表时间：
1984-02
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通讯作者：
Krol Rc;S. L. Knuth;Donald Bartlett
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作者：
Krol Rc;S. L. Knuth;Donald Bartlett
我们记录了12名清醒的正常受试者在每公斤体重饮用1毫升酒精前后的通气和颏舌肌肌电图活动。在安静的室内空气呼吸和高碳酸血症再呼吸期间进行测量。酒精没有改变每分钟通气量、呼吸模式或对CO2的呼吸反应，但在安静呼吸和高碳酸血症时，它显著降低了颏舌活动。男性受试者的效果比女性受试者更一致。这些结果表明，颏舌肌的呼吸活动的神经机制更容易受到抑郁症的酒精比那些服务的肌肉的排泄泵。这种易感性可能是重要的加重酒精的阻塞性呼吸暂停在睡眠中。
We recorded ventilation and genioglossal electromyographic activity in 12 awake, normal subjects before and after they drank 1 ml of ethyl alcohol per kg of body weight. Measurements were made during quiet room air breathing and during hypercapnic rebreathing. Alcohol did not alter minute ventilation, the pattern of breathing, or the ventilatory response to CO2, but it significantly reduced genioglossal activity in both quiet breathing and hypercapnia. The effect was more consistent in male than in female subjects. These results indicate that the neural mechanisms underlying the respiratory activity of the genioglossus are more susceptible to depression by alcohol than those serving the muscles of the ventilatory pump. This susceptibility may be important in the exacerbation by alcohol of obstructive apnea during sleep.