The effect of morphine on the electrophysiological activity of the hypothalamic luteinizing hormone-releasing hormone pulse generator in the rhesus monkey.
The effect of morphine on the electrophysiological activity of the hypothalamic luteinizing hormone-releasing hormone pulse generator in the rhesus monkey.
复制标题
吗啡对恒河猴下丘脑黄体生成素释放激素脉冲发生器电生理活性的影响。
DOI：
10.1159/000124605
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发表时间：
1986
影响因子：
4.1
通讯作者：
Knobil,E
中科院分区：
文献类型：
--
作者：
Kesner,JS;Kaufman,JM;Wilson,RC;Kuroda,G;Knobil,E
在去卵巢的恒河猴，黄体生成素(LHRH)脉冲发生活动的电生理表现被吗啡阻断，并被纳洛酮重新启动。这些反应分别在静脉注射药物后1分钟和2分钟内消失。纳洛酮单独给药不起作用。这些结果支持阿片类药物通过作用于下丘脑LHRH脉冲发生器来调节搏动性促性腺激素释放的观点。
In ovariectomized rhesus monkeys, the electrophysiological manifestation of luteinizing hormone-releasing hormone (LHRH)pulsegenerator activity was arrestedby morphine and reinitiatedby naloxone. These responses werenoted within 1 and 2 min, respectively, after the intravenous injection of the drugs. Naloxone given alone had no effect. These results support the view that opioids modulate pulsatile gonadotropin release by an action on the hypothalamic LHRH pulse generator.