Cytoskeletal Transport, Reorganization, and Fusion Regulation in Mast Cell-Stimulus Secretion Coupling.
Cytoskeletal Transport, Reorganization, and Fusion Regulation in Mast Cell-Stimulus Secretion Coupling.
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DOI：
10.3389/fcell.2021.652077
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发表时间：
2021
影响因子：
5.5
通讯作者：
Blank U
中科院分区：
文献类型：
--
作者：
Ménasché G;Longé C;Bratti M;Blank U
肥大细胞在过敏和许多慢性炎症性疾病中的作用是众所周知的。它们在刺激时释放，例如，通过IgE受体，许多生物活性化合物从细胞质分泌颗粒。颗粒分泌的调节及其与细胞骨架和运输机制的相互作用最近才开始被理解。这些研究提供了新的见解之间的相互作用的分泌机制和细胞骨架元素的调控脱粒过程。他们提出了这两个系统的紧密耦合，这意味着一系列特定的信号效应器和适配器分子。在这里，我们回顾最近的知识，描述信号事件调节细胞骨架重组和分泌颗粒运输机械与膜融合机制，发生在肥大细胞脱粒。对MC生物学的新见解提供了治疗人类过敏性和炎症性疾病的新策略，其目标是影响颗粒储存有害释放的后期步骤，从而保持调节细胞因子分泌完整。
Mast cells are well known for their role in allergies and many chronic inflammatory diseases. They release upon stimulation, e.g., via the IgE receptor, numerous bioactive compounds from cytoplasmic secretory granules. The regulation of granule secretion and its interaction with the cytoskeleton and transport mechanisms has only recently begun to be understood. These studies have provided new insight into the interaction between the secretory machinery and cytoskeletal elements in the regulation of the degranulation process. They suggest a tight coupling of these two systems, implying a series of specific signaling effectors and adaptor molecules. Here we review recent knowledge describing the signaling events regulating cytoskeletal reorganization and secretory granule transport machinery in conjunction with the membrane fusion machinery that occur during mast cell degranulation. The new insight into MC biology offers novel strategies to treat human allergic and inflammatory diseases targeting the late steps that affect harmful release from granular stores leaving regulatory cytokine secretion intact.
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DOI：
10.1172/jci87492
发表时间：
2016-11-01
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Ang WX;Church AM;Kulis M;Choi HW;Burks AW;Abraham SN
通讯作者：
Abraham SN
影响因子：
15.9
作者：
Cote, Marjorie;Menager, Mickael M.;de Saint Basile, Genevieve
通讯作者：
de Saint Basile, Genevieve
影响因子：
64.8
作者：
Ali, K;Bilancio, A;Vanhaesebroeck, B
通讯作者：
Vanhaesebroeck, B
影响因子：
32.4
作者：
Cruse G;Beaven MA;Ashmole I;Bradding P;Gilfillan AM;Metcalfe DD
通讯作者：
Metcalfe DD
影响因子：
4.8
作者：
Bielopolski, Noa;Lam, Alice D.;Ashery, Uri
通讯作者：
Ashery, Uri