Higher Plasma LDL-Cholesterol is Associated with Preserved Executive and Fine Motor Functions in Parkinson's Disease.
Higher Plasma LDL-Cholesterol is Associated with Preserved Executive and Fine Motor Functions in Parkinson's Disease.
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DOI：
10.14336/ad.2015.1030
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发表时间：
2016-05
影响因子：
7.4
通讯作者：
Huang X
中科院分区：
文献类型：
--
作者：
Sterling NW;Lichtenstein M;Lee EY;Lewis MM;Evans A;Eslinger PJ;Du G;Gao X;Chen H;Kong L;Huang X
血浆低密度脂蛋白（LDL）胆固醇与帕金森病（PD）的风险和认知功能的年龄相关变化有关。这项前瞻性研究检查了基线血浆LDL-胆固醇与PD和匹配对照组中认知变化之间的关系。在基线时获得64例非痴呆PD受试者（62.7 ± 7.9岁）和64例对照受试者（61.3 ± 6.8岁）的空腹血浆LDL-胆固醇水平。受试者在基线、18个月和36个月时接受了全面的神经心理学测试。线性混合效应模型用于评估基线LDL-胆固醇水平和纵向认知变化之间的关系。在基线时，与对照组相比，PD患者的精细运动（p<0.0001）、执行集移位（p=0.018）和心理处理速度（p=0.049）评分较低。纵向上，与对照组相比，对照组精细运动和记忆测试评分改善（p=0.044和p=0.003），而PD患者的精细运动技能丧失显著加速（p=0.002）。然而，在PD组中，随着时间的推移，更高的LDL-胆固醇水平与改善的执行集转移（β=0.003，p<0.001）和精细运动评分（β=0.002，p=0.030）相关。对照组中不存在这些关联（p>0.7）。PD和对照组之间的胆固醇-执行集转移关联显著不同（交互作用p=0.005），而胆固醇-精细运动关联差异未达到显著性（交互作用，p=0.104）。总之，随着时间的推移，较高的血浆LDL-胆固醇水平与PD患者更好的执行功能和精细运动表现相关，这两者都可能反映了对黑质纹状体介导的影响。这些结果的确认和阐明所涉及的机制是必要的，并可能导致可行的治疗策略。
Plasma low density lipoprotein (LDL) cholesterol has been associated both with risk of Parkinson’s disease (PD) and with age-related changes in cognitive function. This prospective study examined the relationship between baseline plasma LDL-cholesterol and cognitive changes in PD and matched Controls. Fasting plasma LDL-cholesterol levels were obtained at baseline from 64 non-demented PD subjects (62.7 ± 7.9 y) and 64 Controls (61.3 ± 6.8 y). Subjects underwent comprehensive neuropsychological testing at baseline, 18-, and 36-months. Linear mixed-effects modeling was used to assess the relationships between baseline LDL-cholesterol levels and longitudinal cognitive changes. At baseline, PD patients had lower scores of fine motor (p<0.0001), executive set shifting (p=0.018), and mental processing speed (p=0.049) compared to Controls. Longitudinally, Controls demonstrated improved fine motor and memory test scores (p=0.044, and p=0.003), whereas PD patients demonstrated significantly accelerated loss in fine motor skill (p=0.002) compared to Controls. Within the PD group, however, higher LDL-cholesterol levels were associated with improved executive set shifting (β=0.003, p<0.001) and fine motor scores (β=0.002, p=0.030) over time. These associations were absent in Controls (p>0.7). The cholesterol - executive set shifting association differed significantly between PDs and Controls (interaction p=0.005), whereas the cholesterol - fine motor association difference did not reach significance (interaction, p=0.104). In summary, higher plasma LDL-cholesterol levels were associated with better executive function and fine motor performance over time in PD, both of which may reflect an effect on nigrostriatal mediation. Confirmation of these results and elucidation of involved mechanisms are warranted, and might lead to feasible therapeutic strategies.