Cell Cultured Chondrocyte Implantation and Scaffold Techniques for Osteochondral Talar Lesions
Cell Cultured Chondrocyte Implantation and Scaffold Techniques for Osteochondral Talar Lesions
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DOI：
10.1016/j.fcl.2012.12.008
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发表时间：
2013-03-01
影响因子：
1.5
通讯作者：
Makwana, Nilesh
中科院分区：
文献类型：
--
作者：
Johnson, Ben;Lever, Caroline;Makwana, Nilesh
细胞培养技术已经在骨软骨缺损中获得了兴趣和普及，因为与骨髓刺激方法不同，纤维软骨填充缺损，它们允许具有更好刚度，弹性和磨损特性的“透明样软骨”的再生。踝关节骨软骨缺损是一种罕见的，但具有挑战性的问题，以治疗年轻的活跃患者。如果放任不管，它们会导致疼痛和功能下降，并有可能导致关节进行性退行性变化。细胞培养和支架技术在踝关节的临床结果，虽然仍然受到小型研究和中期随访的限制，但肯定是令人鼓舞的。
Cell cultured techniques have gained interest and popularity in osteochondral defects because, unlike bone marrow stimulation methods, where fibrocartilage fills the defect, they allow for the regeneration of "hyaline-like cartilage" with better stiffness, resilience, and wear characteristics. Osteochondral defects in the ankle are a rare but challenging problem to treat in young active patients. If left alone, they can cause pain and reduced function and risk progressive degenerative changes in the joint. Clinical results of cell cultured and scaffold technology in the ankle, although still limited by small studies and midterm follow-up, are certainly encouraging.