Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera
Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera
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DOI：
10.1016/j.bmcl.2005.10.096
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发表时间：
2006-02-15
影响因子：
2.7
通讯作者：
Liu, Y
中科院分区：
文献类型：
--
作者：
Zhang, XF;Wang, HM;Liu, Y
从芦荟中分离到两个新的二氢香豆素衍生物，化合物1和2。通过x射线晶体衍射分析和大量的一维、二维核磁共振光谱数据确定了它们的结构。这两种物质对超氧自由基和羟基自由基都具有明显的抗氧化活性。只有I在大鼠腹膜巨噬细胞氧呼吸爆发中表现出明显的免疫调节活性，增加吞噬活性，刺激超氧阴离子的产生。(c) 2005 Elsevier Ltd版权所有。
Two new dihydrocoumarin derivatives, compounds 1 and 2, were isolated from Aloe vera. Their structures were determined by X-ray crystallographic diffraction analysis and extensive 1D, 2D NMR spectroscopic data. Both of them evidently sit owed antioxidant activity against superoxide and hydroxyl radicals. Only I obviously exhibited immunomodulatory activity in relation to increasing the phagocytic activity and stimulating the production of superoxide anions in the oxygen respiratory burst of rat peritoneal macrophages. (c) 2005 Elsevier Ltd. All rights reserved.