A new short and simple health-related quality of life measurement for paediatric rheumatic diseases: initial validation in juvenile idiopathic arthritis
A new short and simple health-related quality of life measurement for paediatric rheumatic diseases: initial validation in juvenile idiopathic arthritis
复制标题
DOI：
10.1093/rheumatology/keq065
复制
发表时间：
2010-07-01
期刊：
影响因子：
5.5
通讯作者：
Ravelli, Angelo
中科院分区：
文献类型：
--
作者：
Filocamo, Giovanni;Schiappapietra, Benedetta;Ravelli, Angelo
Objective.目的：建立并验证一种新的、简单的评估幼年特发性关节炎（JIA）患儿健康相关生活质量（HRQL）的方法。儿科流变学生活质量量表（PRQL）是一份10项问卷，探讨两个领域的HRQL：身体健康（PhH）和心理社会健康（PsH）。通过评估472名JIA患者和800名健康儿童，完成了父母代理报告和儿童自我报告版本的仪器的验证。验证分析包括可行性评估、表面和内容效度、结构和区分能力、内部结构和一致性、重测信度、对临床变化的反应性和最小临床重要差异。PRQL被认为是可行的，并具有面效度和内容效度。PRQL评分在预测范围内与大多数其他JIA结局指标相关，从而证明了良好的结构效度，并在不同疾病严重程度之间进行了区分。内部结构的评估（因子分析）显示，PHH和PsH分量表确定两个明确分离的域。内部一致性（Cronbach’s alpha）为0.86。重测信度的组内相关系数为0.91。PRQL显示反应良好，改善患者的标准化反应平均值为0.67。总体而言，PRQL似乎更能够捕捉物理HRQL比心理社会HRQL。结论。PRQL被认为具有良好的测量性能，因此，是一个有效的工具，用于评估HRQL儿童JIA。该工具主要用于标准临床护理。
Objective. To develop and validate a new short and simple measure of health-related quality of life (HRQL) in children with juvenile idiopathic arthritis (JIA).Methods. The Paediatric Rheumatology Quality of Life Scale (PRQL) is a 10-item questionnaire that explores HRQL in two domains: physical health (PhH) and psychosocial health (PsH). Validation of the parent proxy report and child self-report versions of the instrument was accomplished by evaluating 472 JIA patients and similar to 800 healthy children. Validation analyses included assessment of feasibility, face and content validity; construct and discriminative ability; internal structure and consistency; test-retest reliability; responsiveness to clinical change; and minimal clinically important difference.Results. The PRQL was found to be feasible and to possess both face and content validity. The PRQL score correlated in the predicted range with most of the other JIA outcome measures, thereby demonstrating good construct validity, and discriminated well between different levels of disease severity. Assessment of internal structure (factor analysis) revealed that the PhH and PsH subscales identify two unambiguously separated domains. The internal consistency (Cronbach's alpha) was 0.86. The intraclass correlation coefficient for test-retest reliability was 0.91. The PRQL revealed fair responsiveness, with a standardized response mean of 0.67 in improved patients. Overall, the PRQL appeared to be more able to capture physical HRQL than psychosocial HRQL.Conclusion. The PRQL was found to possess good measurement properties and is, therefore, a valid instrument for the assessment of HRQL in children with JIA. This tool is primarily proposed for use in standard clinical care.