Eosinophil ablation and tumor development
Eosinophil ablation and tumor development
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DOI：
10.1016/s1368-8375(99)00023-8
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发表时间：
1999-09-01
期刊：
影响因子：
4.8
通讯作者：
Weller, PF
中科院分区：
文献类型：
--
作者：
Wong, DTW;Bowen, SM;Weller, PF
鳞状细胞癌组织中嗜酸性粒细胞增多早已被认识，然而，嗜酸性粒细胞在肿瘤发展中的作用仍不清楚。研究报告了肿瘤相关组织嗜酸性粒细胞增多症（TATE）患者的有利和不利预后。本研究旨在阐明嗜酸性粒细胞在鳞状细胞癌发生发展中的潜在作用，并为今后的研究提供实验模型。发现致癌物诱导的仓鼠口腔癌模型满足这些目标。嗜酸性粒细胞逐渐浸润到致癌物诱导的口腔癌模型中。我们现在证明，TATE是完全废除使用的抗白细胞介素-5单克隆抗体（mAb）制备，TRFK-5。临床观察结果显示，TRFK-5处理的仓鼠表现出较小的肿瘤负荷和延迟的肿瘤发生。结果表明，抗白细胞介素5抗体治疗可能会延迟和/或抑制肿瘤的发展，嗜酸性粒细胞可能有肿瘤促进作用。(C)1999爱思唯尔科技有限公司。保留所有权利。
Tissue eosinophilia in squamous cell carcinoma has long been recognized; however, the role of eosinophils in tumor development remains unclear. Studies have reported both favorable and unfavorable prognoses for patients with tumors exhibiting tumor-associated tissue eosinophilia (TATE). This study seeks to elucidate the potential role of the eosinophil in squamous cell carcinoma development and provide an experimental model for future studies. The carcinogen-induced hamster oral cancer model was found to fulfill these objectives. Eosinophils progressively infiltrate into this carcinogen-induced oral cancer model. We now demonstrate that TATE is completely abolished by the use of an anti-interleukin-5 monoclonal antibody (mAb) preparation, TRFK-5. Clinical observations revealed that TRFK-5-treated hamsters exhibited smaller tumor burden and delayed onset of tumor development. The results suggest that anti-interleukin5 antibody treatment may delay and/or inhibit tumor development, and that eosinophils may have a tumor-promoting role. (C) 1999 Elsevier Science Ltd. All rights reserved.