Atractylodin attenuates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome and TLR4 pathways
Atractylodin attenuates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome and TLR4 pathways
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DOI：
10.1016/j.jphs.2017.11.010
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发表时间：
2018-04-01
影响因子：
3.5
通讯作者：
Bian, Chuanzhou
中科院分区：
文献类型：
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作者：
Tang, Fayin;Fan, Kefeng;Bian, Chuanzhou
急性肺损伤（acute lung injury，ALI）是由不受控制的肺部炎症引起的，死亡率高.白藜芦醇（Atr）是一种聚乙烯炔类化合物，具有抗炎作用。因此，我们的目的是研究Atr对脂多糖（LPS）诱导的炎症反应ALI的保护作用。结果表明，Atr治疗不仅能明显减轻LPS诱导的肺组织病理学改变，还能降低髓过氧化物酶（MPO）活性、肺湿干重比、蛋白渗出和炎性细胞浸润。Atr还能抑制BALF中肿瘤坏死因子（TNF）-α、白细胞介素（IL）-6、IL-1 β和单核细胞趋化蛋白（MCP）-1的分泌。进一步的研究表明Atr的这种抑制作用是由于抑制核苷酸结合域（NOD-）样受体蛋白3（NLRP 3）炎性小体和Toll样受体4（TLR 4）的激活，可能有助于其抗炎作用。总的来说，这些研究结果表明，Atr可能是一个有效的候选人，减轻LPS诱导的炎症反应。(C)2018作者制作和主办：Elsevier B.V.
Acute lung injury (ALI) arises from uncontrolled pulmonary inflammation with high mortality rates. Atractylodin (Atr) is a polyethylene alkynes and has been reported to possess anti-inflammation effect. Thus, we aimed to investigate the protective effect of Atr on lipopolysaccharide (LPS)-induced inflammatory responses ALI. The results indicated that Atr treatment not only significantly attenuated LPS-stimulated histopathological changes but also lessened the myeloperoxidase (MPO) activity, the wet-to-dry weight ratio of the lungs, protein leakage and infiltration of inflammatory cells. Moreover, Atr inhibited the tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-1 beta and monocyte chemoattractant protein (MCP)-1 secretion in BALF. Further study demonstrated that such inhibitory effects of Atr were due to suppression of nucleotide-binding domain-(NOD-) like receptor protein 3 (NLRP3) inflammasome and toll like receptor 4 (TLR4) activation, likely contributing to its anti-inflammatory effects. Collectively, these findings suggest that Atr may be an effective candidate for alleviating LPS-induced inflammatory responses. (C) 2018 The Authors. Production and hosting by Elsevier B.V.