COMPLEX-SPECIFIC IMMUNOGLOBULIN-M ANTIBODY PATTERNS IN HUMANS INFECTED WITH ALPHAVIRUSES
COMPLEX-SPECIFIC IMMUNOGLOBULIN-M ANTIBODY PATTERNS IN HUMANS INFECTED WITH ALPHAVIRUSES
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DOI：
10.1128/jcm.23.1.155-159.1986
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发表时间：
1986-01-01
影响因子：
9.4
通讯作者：
SUHARYONO, W
中科院分区：
文献类型：
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作者：
CALISHER, CH;ELKAFRAWI, AO;SUHARYONO, W
用免疫球蛋白M（IgM）抗体捕获酶免疫法检测血清学证实的东部马脑炎、西部马脑炎、Pogosta（Ockelbo）、Mayaro、Ross River和基孔肯雅病毒感染的人血清。检测诊断有用的IgM抗体滴度，并用9种异源甲病毒测试具有高IgM抗体滴度的所选血清的IgM抗体。结果为IgM抗体的复杂特异性提供了证据，并表明该试验在个案和疫情中的有用性。
Sera from humans with serologiaclly confirmed eastern equine encephalitis, western encephalitis, Pogosta (Ockelbo), Mayaro, Ross River, and chikungunya virus infections were tested by immunoglobulin M (IgM) antibody capture enzyme immunoassay. Diagnostically useful IgM antibody titers were detected, and selected sera with high IgM antibody titers were tested for IgM antibody with nine heterologous alphaviruses. The results provide evidence for the complex specificity of IgM antibody and indicate the usefulness of this test in both individual cases and epidemic situations.